Roller Compaction of Hydrophilic Extended Release Tablets—Combined Effects of Processing Variables and Drug/Matrix Former Particle Size
| Autor: | Bindhumadhavan Gururajan, Farhad Tajarobi, Susanna Abrahmsén-Alami, Anne Juppo, Johanna Heiman |
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| Rok vydání: | 2014 |
| Předmět: |
Materials science
Chemistry Pharmaceutical Drug Compounding Compaction Pharmaceutical Science Ibuprofen Work hardening Aquatic Science Excipients Granulation Hypromellose Derivatives Tensile Strength Drug Discovery Ultimate tensile strength Pressure Particle Size Composite material Porosity Ecology Evolution Behavior and Systematics Acetaminophen Ecology Granule (cell biology) technology industry and agriculture Percolation threshold General Medicine body regions Delayed-Action Preparations Particle size Powders Hydrophobic and Hydrophilic Interactions Agronomy and Crop Science Research Article Tablets |
| Zdroj: | AAPS PharmSciTech. 16:267-277 |
| ISSN: | 1530-9932 |
| Popis: | The present study shows that roller compaction (RC) can successfully be used as a granulation method to prepare hydroxypropyl methylcellulose (HPMC)-based extended release matrix tablets containing a high drug load, both for materials deforming mainly by fragmentation (paracetamol) as for those having mainly plastic deformation (ibuprofen). The combined effect of RC process variables and composition on the manufacturability of HPMC tablets was investigated. Standard wet granulation grade HPMC was compared with a larger particle size direct compressible HPMC grade. Higher roll pressure was found to result in larger paracetamol granules and narrower granule particle size distributions, especially for formulations containing smaller size HPMC. However, for ibuprofen, no clear effect of roll pressure was observed. High roll pressure also resulted in denser ribbon and less bypass fines during RC. Loss of compactibility was observed for granules compared to powder blends, which was found to be related to differences in granule porosity and morphology. Using the large-sized HPMC grade did in some cases result in lower tensile strength tablets but had the advantage to improve the powder flow into the roller compactor. This work also indicates that when the HPMC level lies near the percolation threshold, significant changes can occur in the drug release rate due to changes in other factors (raw material characteristics and processing). |
| Databáze: | OpenAIRE |
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