fMRI brain activation in patients with insomnia disorder during a working memory task
| Autor: | Seung Gul Kang, Jungsun Lee, Hee Young Hwang, Young Don Son, Seong-Jin Cho, Jae Myeong Kang |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Neurology Neuroimaging Polysomnography Audiology 03 medical and health sciences 0302 clinical medicine Sleep Initiation and Maintenance Disorders mental disorders medicine Insomnia Humans Effects of sleep deprivation on cognitive performance Psychiatry Sleep disorder Resting state fMRI medicine.diagnostic_test business.industry Working memory medicine.disease Magnetic Resonance Imaging Memory Short-Term 030228 respiratory system Otorhinolaryngology Female Neurology (clinical) medicine.symptom business Functional magnetic resonance imaging 030217 neurology & neurosurgery |
| Zdroj: | Sleep and Breathing. 22:487-493 |
| ISSN: | 1522-1709 1520-9512 |
| DOI: | 10.1007/s11325-017-1575-5 |
| Popis: | This study used functional magnetic resonance imaging (fMRI) to investigate differences in the functional brain activation of patients with insomnia disorder (n = 21, mean age = 36.6) and of good sleepers (n = 26, mean age = 33.2) without other comorbidities or structural brain abnormalities during a working memory task. All participants completed a clinical questionnaire, were subjected to portable polysomnography (PSG), and performed the working memory task during an fMRI scan. The subjects who were suspected of major sleep disorder and comorbid psychiatric disorders except insomnia disorder were excluded. To compare the brain activation on working memory from the insomnia group with those from the good-sleeper group, a two-sample t test was performed. Statistical significance was determined using 3DClustSim with the updated algorithm to obtain a reasonable cluster size and p value for each analysis. We observed higher levels of brain activation in the right lateral inferior frontal cortex and the right superior temporal pole in the insomnia group compared to good sleepers (cluster-based multiple comparison correction, p |
| Databáze: | OpenAIRE |
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