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Statement of problem: How the corrosion properties of cobalt-chromium (Co-Cr) and Ti (Ti-6Al-4V) alloys, frequently used in dental prostheses, are affected by different production methods is unclear. Purpose: The purpose of this in vitro study was to compare Co-Cr and Ti-6Al-4V alloys produced by computer-aided design and computer-aided manufacturing (CAD-CAM) milling or laser sintering in terms of corrosion, ion release, and surface hardness. Material and methods: Co-Cr and Ti-6Al-4V specimens were produced by CAD-CAM milling and direct metal laser sintering/selective laser sintering techniques. Testing included Vickers hardness and then open circuit potential (OCP), Tafel extrapolation, and static immersion to determine the corrosion behavior. The study used an inductively coupled plasma mass spectrometer to measure ion release. The data were analyzed by using the Kruskal-Wallis and Mann-Whitney U tests, with Bonferroni correction (α=.05). Results: The Ti-6Al-4V laser-sintered group showed the highest Vickers hardness value (P |