UVA radiation induced ultrafast electron transfer from a food carcinogen benzo[a]pyrene to organic molecules, biological macromolecules, and inorganic nano structures
| Autor: | Karthik Lakshman, Soumik Sarkar, Joydeep Dutta, Samir Kumar Pal, Soma Banerjee |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Circular dichroism
Stereochemistry Ultraviolet Rays Electrons Photochemistry Fluorescence spectroscopy Electron Transport chemistry.chemical_compound Electron transfer Materials Chemistry medicine Benzo(a)pyrene Benzoquinones Animals Humans Physical and Theoretical Chemistry Carcinogen Nanotubes Circular Dichroism Serum Albumin Bovine DNA Human serum albumin Surfaces Coatings and Films Spectrometry Fluorescence chemistry Carcinogens Pyrene Cattle Zinc Oxide Reactive Oxygen Species Macromolecule medicine.drug |
| Zdroj: | The journal of physical chemistry. B. 117(14) |
| ISSN: | 1520-5207 |
| Popis: | Reactions involving electron transfer (ET) and reactive oxygen species (ROS) play a pivotal role in carcinogenesis and cancer biochemistry. Our present study emphasizes UVA radiation induced ET reaction as one of the key aspects of a potential carcinogen, benzo[a]pyrene (BP), in the presence of a wide variety of molecules covering organic p-benzoquinone (BQ), biological macromolecules like calf-thymus DNA (CT-DNA), human serum albumin (HSA) protein, and inorganic zinc oxide (ZnO) nanorods (NRs). Steady-state and picosecond-resolved fluorescence spectroscopy have been used to monitor such ET reactions. Physical consequences of BP association with CT-DNA have been investigated through temperature-dependent circular dichroism (CD) spectroscopy. The temperature-dependent steady-state, picosecond-resolved fluorescence lifetime and anisotropy studies reveal the effect of temperature on the perturbation of such ET reactions from BP to biological macromolecules, highlighting their temperature-dependent association. Furthermore, the electron-donating property of BP has been corroborated by measuring wavelength-dependent photocurrent in a BP-anchored ZnO NR-based photodevice, offering new physical insights for the carcinogenic study of BP. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|