Best practices for time-resolved serial synchrotron crystallography

Autor: Eike C. Schulz, Briony A. Yorke, Arwen R. Pearson, Pedram Mehrabi
Rok vydání: 2022
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Zdroj: Acta Crystallographica. Section D, Structural Biology
'Acta Crystallographica D ', vol: 78, pages: 14-29 (2022)
ISSN: 2059-7983
DOI: 10.1107/s2059798321011621
Popis: The key factors that should be considered during the planning and execution of a time-resolved crystallographic experiment are discussed, with a focus on time-resolved serial synchrotron crystallography.
With recent developments in X-ray sources, instrumentation and data-analysis tools, time-resolved crystallographic experiments, which were originally the preserve of a few expert groups, are becoming simpler and can be carried out at more radiation sources, and are thus increasingly accessible to a growing user base. However, these experiments are just that: discrete experiments, not just ‘data collections’. As such, careful planning and consideration of potential pitfalls is required to enable a successful experiment. Here, some of the key factors that should be considered during the planning and execution of a time-resolved structural study are outlined, with a particular focus on synchrotron-based experiments.
Databáze: OpenAIRE
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