Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses

Autor: Balimkiz Senman, E. Ashley Moseman, Michael P Flynn, Philip W. Askenase, Silke Paust, Marian Szczepanik, Bao-Zhong Wang, Amalio Telenti, Harvinder S. Gill, Ulrich H. von Andrian, Richard W. Compans
Rok vydání: 2010
Předmět:
Cytotoxicity
Immunologic
Adoptive cell transfer
Immunology
Mice
Transgenic
Cell Separation
Biology
Adaptive Immunity
03 medical and health sciences
Interleukin 21
Mice
0302 clinical medicine
Immune system
NK-92
Antigen
Immunology and Allergy
Animals
030304 developmental biology
Receptors
CXCR6
Mice
Knockout
Receptors
CXCR
0303 health sciences
Adaptive Immunity/immunology
Adoptive Transfer
Chemotaxis
Leukocyte/immunology
Cytotoxicity
Immunologic/immunology
Flow Cytometry
Haptens/immunology
Immunologic Memory/immunology
Killer Cells
Natural/immunology
Killer Cells
Natural/metabolism
Liver/cytology
Liver/immunology
Lymphocyte Subsets/immunology
Lymphocyte Subsets/metabolism
Mice
Inbred C57BL
Receptors
CXCR/immunology
Receptors
CXCR/metabolism
Virus Diseases/immunology
Viruses/immunology
Janus kinase 3
Acquired immune system
Virology
Lymphocyte Subsets
3. Good health
Killer Cells
Natural
Chemotaxis
Leukocyte
Liver
Virus Diseases
Viruses
Interleukin 12
Haptens
Immunologic Memory
030215 immunology
Zdroj: Nature immunology
Nature immunology, vol. 11, no. 12, pp. 1127-1135
DOI: 10.1038/ni.1953
Popis: Hepatic natural killer (NK) cells mediate antigen-specific contact hypersensitivity (CHS) in mice deficient in T cells and B cells. We report here that hepatic NK cells, but not splenic or naive NK cells, also developed specific memory of vaccines containing antigens from influenza, vesicular stomatitis virus (VSV) or human immunodeficiency virus type 1 (HIV-1). Adoptive transfer of virus-sensitized NK cells into naive recipient mice enhanced the survival of the mice after lethal challenge with the sensitizing virus but not after lethal challenge with a different virus. NK cell memory of haptens and viruses depended on CXCR6, a chemokine receptor on hepatic NK cells that was required for the persistence of memory NK cells but not for antigen recognition. Thus, hepatic NK cells can develop adaptive immunity to structurally diverse antigens, an activity that requires NK cell-expressed CXCR6.
Databáze: OpenAIRE
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