Microstructural white matter changes preceding white matter hyperintensities in migraine
| Autor: | Lenore J. Launer, Julien Milles, Baldur van Lew, Paul A. M. Hofman, Inge H. Palm-Meinders, Enrico B Arkink, Mark A. van Buchem, Mark C. Kruit, Michel D. Ferrari, Hille Koppen, Gisela M. Terwindt |
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| Přispěvatelé: | Beeldvorming, MUMC+: DA BV Medisch Specialisten Radiologie (9), RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Aura Migraine Disorders Population Brain tissue Article White matter 03 medical and health sciences 0302 clinical medicine HEADACHE Risk Factors Internal medicine Humans Medicine Magnetization transfer AURA education education.field_of_study ABNORMALITIES business.industry BRAIN-TISSUE Leukoaraiosis Brain Middle Aged MAGNETIZATION-TRANSFER medicine.disease Magnetic Resonance Imaging White Matter White matter changes Hyperintensity 030227 psychiatry medicine.anatomical_structure Migraine Cardiology Female Neurology (clinical) business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Neurology, 93(7), E688-E694. LIPPINCOTT WILLIAMS & WILKINS Neurology |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | ObjectiveWe used magnetization transfer imaging to assess white matter tissue integrity in migraine, to explore whether white matter microstructure was more diffusely affected beyond visible white matter hyperintensities (WMHs), and to explore whether focal invisible microstructural changes precede visible focal WMHs in migraineurs.MethodsWe included 137 migraineurs (79 with aura, 58 without aura) and 74 controls from the Cerebral Abnormalities in Migraine, an Epidemiological Risk Analysis (CAMERA) study, a longitudinal population-based study on structural brain lesions in migraine patients, who were scanned at baseline and at a 9-year follow-up. To assess microstructural brain tissue integrity, baseline magnetization transfer ratio (MTR) values were calculated for whole brain white matter. Baseline MTR values were determined for areas of normal-appearing white matter (NAWM) that had progressed into MRI-detectable WMHs at follow-up and compared to MTR values of contralateral NAWM.ResultsMTR values for whole brain white matter did not differ between migraineurs and controls. In migraineurs, but not in controls, NAWM that later progressed to WMHs at follow-up had lower mean MTR (mean [SD] 0.354 [0.009] vs 0.356 [0.008], p = 0.047) at baseline as compared to contralateral white matter.ConclusionsWe did not find evidence for widespread microstructural white matter changes in migraineurs compared to controls. However, our findings suggest that a gradual or stepwise process might be responsible for evolution of focal invisible microstructural changes into focal migraine-related visible WMHs. |
| Databáze: | OpenAIRE |
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