Pharmacokinetics: metabolism and renal excretion of quinolones in man
| Autor: | P. J. M. Guelen, W. J. A. Wijnands, Yechiel A. Hekster, Tom B. Vree, A. M. Baars |
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| Rok vydání: | 1986 |
| Předmět: |
Drug
medicine.medical_specialty media_common.quotation_subject Pharmaceutical Science Renal function Intestinal absorption Nalidixic Acid Pharmacokinetics Anti-Infective Agents Internal medicine Medicine Humans Pharmacology (medical) media_common Pharmacology Gastrointestinal tract business.industry Half-life Metabolism Hydrogen-Ion Concentration Kinetics Endocrinology Intestinal Absorption Renal physiology Quinolines Kidney Diseases business Half-Life |
| Zdroj: | Pharmaceutisch weekblad. Scientific edition. 8(1) |
| ISSN: | 0167-6555 |
| Popis: | The quinolones are relatively poorly absorbed from the gastrointestinal tract. The elimination proceeds mainly by renal excretion. The half-life of elimination depends on the molecular structure and varies between 2 and 10 h. Impaired kidney function is expected to increase the half-life of elimination, though this effect is not always observed. Since the 4-oxo-metabolites show a higher renal clearance than the parent drug, renal impairment will result in a cumulation of the metabolites in the body. |
| Databáze: | OpenAIRE |
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