Elimination of influences of the ACTN3 R577X variant on oxygen uptake by endurance training in healthy individuals
| Autor: | Patricia A. Oliveira, Carlos Eduardo Negrão, Jeferson Luis da Silva, Guilherme Barreto Alves, José Ribeiro Lemos Jr, José Eduardo Krieger, Wladimir Bolani, Cleber Renê Alves, Alexandre C. Pereira, Edilamar Menezes de Oliveira, Michelle Silva, Diogo Biagi, Rodrigo Gonçalves Dias |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Genotype Physical Therapy Sports Therapy and Rehabilitation Respiratory compensation Body weight POLIMORFISMO Polymorphism Single Nucleotide Young Adult Endurance training Internal medicine medicine Humans Orthopedics and Sports Medicine Actinin Exercise business.industry Genetic Variation Cardiopulmonary exercise testing Oxygen uptake Healthy Volunteers Endocrinology Phenotype Healthy individuals Physical Endurance Peak vo2 business Anaerobic exercise |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Aim:To study the relationship between the ACTN3 R577X polymorphism and oxygen uptake (VO2) before and after exercise training.Methods:Police recruits (N = 206, 25 ± 4 y) with RR (n = 75), RX (n = 97), and XX (n = 33) genotypes were selected. After baseline measures, they underwent 18 wk of running endurance training. Peak VO2 was obtained by cardiopulmonary exercise testing.Results:Baseline body weight was not different among genotypes. At baseline, XX individuals displayed higher VO2 at anaerobic threshold, respiratory compensation point, and exercise peak than did RR individuals (P < .003). Endurance training significantly increased VO2 at anaerobic threshold, respiratory compensation point, and exercise peak (P < 2 × 10−6), but the differences between XX and RR were no longer observed. Only relative peak VO2 exercise remained higher in XX than in RR genotype (P = .04). In contrast, the increase in relative peak VO2 was greater in RR than in XX individuals (12% vs 6%; P = .02).Conclusion:ACTN3 R577X polymorphism is associated with VO2. XX individuals have greater aerobic capacity. Endurance training eliminates differences in peak VO2 between XX and RR individuals. These findings suggest a ceiling-effect phenomenon, and, perhaps, trained individuals may not constitute an adequate population to explain associations between phenotypic variability and gene variations. |
| Databáze: | OpenAIRE |
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