Innovative haematological parameters for early diagnosis of sepsis in adult patients admitted in intensive care unit
| Autor: | Michela Seghezzi, Cosimo Ottomano, Giuseppe Lippi, Sabrina Buoro, Barbara Manenti, Ivano Riva, Arianna Ghirardi, Tiziano Barbui, Alessandra Carobbio, Paola Dominoni, Gianmariano Marchesi, Alessandra Nasi |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male medicine.medical_specialty Sysmex 030204 cardiovascular system & hematology Immature Platelet Sensitivity and Specificity automated hematology analyzer Pathology and Forensic Medicine law.invention Sepsis sepsis 03 medical and health sciences 0302 clinical medicine law Internal medicine Humans Medicine 030212 general & internal medicine Immature Platelet Fraction liver impairment reticolocytes Intensive care medicine Aged Hematologic Tests Adult patients Receiver operating characteristic biology business.industry C-reactive protein Area under the curve General Medicine Middle Aged medicine.disease Intensive care unit Intensive Care Units Early Diagnosis ROC Curve Area Under Curve biology.protein Population study Female business |
| Popis: | AimsThis study was aimed to investigate the role of erythrocyte, platelet and reticulocyte (RET) parameters, measured by new haematological analyser Sysmex XN and C reactive protein (CRP), for early diagnosis of sepsis during intensive care unit (ICU) stay.MethodsThe study population consisted of 62 ICU patients, 21 of whom developed sepsis during ICU stay and 41 who did not. The performance for early diagnosing of sepsis was calculated as area under the curve (AUC) of receiver operating characteristics curves analysis.ResultsCompared with CRP (AUC 0.81), immature platelet fraction (IPF) (AUC 0.82) showed comparable efficiency for identifying the onset of sepsis. The association with the risk of developing sepsis during ICU stay was also assessed. One day before the onset of sepsis, a decreased of RET% was significantly associated with the risk of developing sepsis (OR=0.35, 95% CI 0.14 to 0.87), whereas an increased of IPF absolute value (IPF#) was significantly associated with the risk of developing sepsis (OR=1.13, 95% CI 1.03 to 1.24) 2 days before the onset of sepsis. The value of CRP was not predictive of sepsis at either time points.ConclusionsIPF# and RET% may provide valuable clinical information for predicting the risk of developing sepsis, thus allowing early management of patients before the onset of clinically evident systemic infections. |
| Databáze: | OpenAIRE |
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