Phosphorylation of recoverin, the calcium-sensitive activator of photoreceptor guanylyl cyclase
| Autor: | H. G. Lambrecht, Karl-Wilhelm Koch |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Guanylyl cyclase
inorganic chemicals genetic structures Lipoproteins Biophysics chemistry.chemical_element Nerve Tissue Proteins Calcium Biochemistry Light adaptation chemistry.chemical_compound Adenosine Triphosphate Structural Biology Recoverin Calcium-binding protein Hippocalcin Genetics Animals Photoreceptor Cells Phosphorylation Eye Proteins Molecular Biology Photoreceptor biology Activator (genetics) Calcium-Binding Proteins Cell Biology Rod Cell Outer Segment eye diseases Cell biology Enzyme Activation enzymes and coenzymes (carbohydrates) chemistry Guanylate Cyclase biology.protein GUCY2D Cattle sense organs Protein Kinases Adenosine triphosphate |
| Zdroj: | FEBS Letters. 294:207-209 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/0014-5793(91)80670-x |
| Popis: | Recoverin, a new calcium binding protein from bovine rod photoreceptor cells, activates guanylyl cyclase below a free calcium concentration of 200 nM. We show here that recoverin is phosphorylated by an endogeneous kinase and Mg-ATP at the same decreased calcium concentration. The calcium-dependent activation of guanylyl cyclase is enhanced in the presence of ATP. We suggest that phosphorylation of recoverin reinforces the stimulation of guanylyl cyclase at decreased calcium concentrations. |
| Databáze: | OpenAIRE |
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