INN or brand name drug prescriptions: a multilevel, cross-sectional study in general practice

Autor: François Gueyffier, Xavier Dode, Florent De Bruyne, Joris Giai, Arnaud Ponçon, Laurent Letrilliart, David Darmon, Cyrille Colin
Přispěvatelé: Collège Universitaire de Médecine Générale [Lyon] (CUMG), Université de Lyon, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Service de Biostatistiques [Lyon], Hospices Civils de Lyon (HCL), Health Service and Performance Research (HESPER), Université de Lyon-Université de Lyon, Pôle Information Médicale Evaluation Recherche (IMER), Service de Pharmacologie Toxicologie, Hospices Civils de Lyon, France, Université Nice Sophia Antipolis - Faculté de Médecine (UNS UFR Médecine), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Nice Sophia Antipolis (... - 2019) (UNS), HAL AMU, Administrateur
Rok vydání: 2018
Předmět:
Male
medicine.medical_specialty
Multivariate analysis
Prescription Drugs
Adolescent
Cross-sectional study
media_common.quotation_subject
Drug prescription
General Practice
030226 pharmacology & pharmacy
Drug Prescriptions
03 medical and health sciences
0302 clinical medicine
Brand name
Generic drug
medicine
Drugs
Generic
Humans
Pharmacology (medical)
030212 general & internal medicine
Medical prescription
Practice Patterns
Physicians'
media_common
Pharmacology
International Nonproprietary Name (INN)
business.industry
Public health
General Medicine
Payment
3. Good health
Incentive
Cross-Sectional Studies
[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie
Family medicine
General practice
Multivariate Analysis
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Female
France
Health Expenditures
business
Zdroj: European Journal of Clinical Pharmacology
European Journal of Clinical Pharmacology, 2019, 75 (2), pp.275-283. ⟨10.1007/s00228-018-2580-8⟩
European Journal of Clinical Pharmacology, Springer Verlag, 2019, 75 (2), pp.275-283. ⟨10.1007/s00228-018-2580-8⟩
ISSN: 1432-1041
0031-6970
DOI: 10.1007/s00228-018-2580-8⟩
Popis: International audience; PurposeThe prescription in International Nonproprietary Names (INN) is a legal obligation for all physicians in France since January 2015. The objective of this study was to analyze the frequency and main factors of INN drug prescribing in general practice.MethodsMulticenter cross-sectional study conducted with 11 interns acting as observers of 23 GP trainers between November 2015 and January 2016. Two evaluators analyzed all GPs’ drug prescriptions to identify INN or brand name prescriptions.ResultsThe database included 4957 drugs prescribed during 1647 visits. Of these, 1462 (29.5% [95% CI 28.2–30.8%]) were prescribed only in INN. According to the multivariate analyses, the factors favoring INN prescribing were as follows: at the drug level, its initial prescribing (OR = 1.4), a nonspecific prescribing objective (OR = 1.6), its listing in the generic drug index with (OR = 7.7) or without (OR = 2.9) efficiency objective included in the payment for public health objectives (PPHO) program, and the oral route of administration (OR from 0.4 for the percutaneous route to 0.2 for the pulmonary route); at the patient level, the male gender (OR = 1.3), the age of 15 years or more (OR = 1.9), and the absence of a long-term condition (OR = 1.3); at the physician level, the reception of a public healthcare insurance representative (OR = 4.1), the nonreception of pharmaceutical sales representatives (OR = 3.0), and the urban practice environment (OR = 2.8).ConclusionsIn 2015, less than one third of drugs were prescribed in INN only in general practice. The use of various incentives and regulatory measures is likely to favor the prescription of INNs by practitioners.
Databáze: OpenAIRE
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