11 C-acetate PET imaging of lung cancer: comparison with 18 F-FDG PET and 99m Tc-MIBI SPET
| Autor: | Yuko Kodama, Takahiro Higuchi, Ryosuke Ikeda, Hisao Tonami, Ichiro Matsunari, Katsuyuki Miura, Suzuka Taki, Kotaro Higashi, Yoshimichi Ueda, Itaru Yamamoto |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Technetium Tc 99m Sestamibi medicine.medical_specialty Lung Neoplasms Acetates Sensitivity and Specificity 18f fdg pet Fluorodeoxyglucose F18 medicine Carcinoma Humans Radiology Nuclear Medicine and imaging Lung cancer Aged Aged 80 and over Lung medicine.diagnostic_test business.industry Reproducibility of Results Cancer General Medicine Pet imaging Middle Aged medicine.disease Carbon medicine.anatomical_structure Positron emission tomography Feasibility Studies Adenocarcinoma Female Radiology Radiopharmaceuticals business Nuclear medicine Tomography Emission-Computed |
| Zdroj: | European Journal of Nuclear Medicine and Molecular Imaging. 31:13-21 |
| ISSN: | 1619-7089 1619-7070 |
| Popis: | Recently carbon-11 acetate (AC) positron emission tomography (PET) has been reported to be of clinical value for the diagnosis of cancer that is negative on fluorine-18 fluorodeoxyglucoce (FDG) PET. We investigated the uptake of AC in lung cancer to determine whether this tracer is of potential value for tumour detection and characterisation, and to compare AC PET imaging with FDG PET and technetium-99m sestamibi (MIBI) single-photon emission tomography (SPET). Twenty-three patients with 25 lung cancers underwent AC and FDG PET. Twenty of 23 patients were also investigated with MIBI SPET. Dynamic images were acquired for 26 min after the injection of 555 MBq of AC. Standardised uptake values (SUVs) and/or tumour to non-tumour activity ratios (T/N) for each tumour were investigated at 10–20 min after AC administration, 40–60 min after administration of 185 MBq FDG and 15–45 min after administration of 555 MBq MIBI. Twenty lung cancers were resected surgically, and the degree of tracer uptake in the primary lesion was correlated with histopathological features (cell dedifferentiation and aggressiveness) and prognosis. Rapid uptake of AC followed by extremely slow clearance was observed. For the purpose of tumour identification, AC PET was inferior to FDG PET in 8 of 25 (32%) lung cancers, and the T/N of AC was lower than that of FDG. However, AC PET was superior to FDG PET in the identification of a slow-growing tumour (bronchiolo-alveolar carcinoma). There was a positive correlation between AC uptake (T/N) and MIBI uptake (T/N) (r=0.799, P |
| Databáze: | OpenAIRE |
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