The Impact of Obstructive Sleep Apnoea and Nasal Continuous Positive Airway Pressure on Circulating Ischaemia-Modified Albumin Concentrations
| Autor: | Fırat Uygur, Bulent Altinsoy, Tacettin Örnek, Murat Can, Fatma Erboy, Hakan Tanriverdi, Meltem Tor, Furuzan Kokturk, Murat Damar, Figen Atalay |
|---|---|
| Přispěvatelé: | Zonguldak Bülent Ecevit Üniversitesi |
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Article Subject Polysomnography medicine.medical_treatment Immunology Serum Albumin Human Newly diagnosed 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Internal medicine lcsh:Pathology medicine Humans Cpap treatment Prospective Studies Continuous positive airway pressure Serum Albumin Morning Sleep Apnea Obstructive Continuous Positive Airway Pressure medicine.diagnostic_test business.industry Albumin Cell Biology Middle Aged nervous system diseases respiratory tract diseases Surgery 030228 respiratory system Clinical Study Cardiology Female Ischaemia modified albumin business Body mass index Biomarkers lcsh:RB1-214 |
| Zdroj: | Mediators of Inflammation, Vol 2016 (2016) Mediators of Inflammation |
| ISSN: | 1466-1861 0962-9351 |
| DOI: | 10.1155/2016/8907314 |
| Popis: | The aim of the present study was to evaluate the impact of obstructive sleep apnoea syndrome (OSAS) and the effects of nasal continuous positive airway pressure (CPAP) on circulating ischaemia-modified albumin (IMA) concentrations. The study included 97 newly diagnosed OSAS patients and 30 nonapnoeic controls. Blood samples were obtained in the morning after polysomnography. After 3 months of CPAP treatment, 31 patients with moderate-severe OSAS were reassessed for serum IMA concentrations. Significantly higher serum IMA concentrations were measured in the OSAS group than in the control group [0.518±0.091absorbance units (ABSU),0.415±0.068ABSU,P<0.001]. Serum IMA concentrations correlated significantly with the apnoea-hypopnoea index, mean SaO2, desaturation index, and C-reactive protein concentrations. Multiple logistic regression analyses showed that OSAS increased the serum IMA concentration independent of age, sex, body mass index, smoking habit, and cardiovascular disease. After 3 months of treatment with CPAP, OSAS patients had significantly lower serum IMA concentrations (0.555±0.062ABSU to0.431±0.063ABSU,P<0.001). The results showed that OSAS is associated with elevated concentrations of IMA, which can be reversed by effective CPAP treatment. |
| Databáze: | OpenAIRE |
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