Cocaine induced synchronous oscillations in central noradrenergic neurons in vitro
| Autor: | Z.E. Hausken, John T. Williams, G.C. Harris |
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| Rok vydání: | 1992 |
| Předmět: |
Male
Central nervous system Biology In Vitro Techniques Inhibitory postsynaptic potential Kynurenic Acid Membrane Potentials Dioxanes Cocaine Postsynaptic potential Idazoxan Oscillometry Monoaminergic medicine Animals Picrotoxin Rats Wistar Evoked Potentials Adrenergic alpha-Antagonists Membrane potential Neurons General Neuroscience Prazosin Strychnine Rats Electrophysiology Kinetics medicine.anatomical_structure Synapses Locus coeruleus Locus Coeruleus Neuroscience Nucleus |
| Zdroj: | Neuroscience. 50(2) |
| ISSN: | 0306-4522 |
| Popis: | Through inhibition of reuptake, cocaine increases monoaminergic tone in the central nervous system. The activities of the neurons within the locus coeruleus play a pivotal role in central noradrenergic transmission and regulate overall levels of arousal and attention. We have found that cocaine in low concentrations (0.3-1.0 microM) induced slow oscillations (0.8 Hz) in membrane potential (2-6 mV). These oscillations were synchronized in neurons throughout the nucleus and were blocked by alpha 2-adrenergic receptor antagonists. The synchrony of these events was thought to arise from within the nucleus, through a combination of spontaneous activity (intrinsic properties) and noradrenergic mediated inhibitory postsynaptic potentials augmented by cocaine. The synchronous firing of noradrenergic neurons may facilitate transmitter release in the widespread projection areas and thus be important for the action of cocaine to increase levels of arousal. |
| Databáze: | OpenAIRE |
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