Complete androgen insensitivity syndrome
| Autor: | Tančić Milina Gajić, Ljiljana Marina, Svetlana Vujovic, Miomira Ivovic, Zorana Arizanovic, Dragan Micic, Dragana Rakovic |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty lcsh:Medicine Diagnosis Differential 03 medical and health sciences Young Adult 0302 clinical medicine Complete androgen insensitivity syndrome 46 XY androgen receptor Multidetector Computed Tomography Hormone replacement therapy (male-to-female) androgen insensitivity syndrome Medicine Humans 030212 general & internal medicine Disorders of sex development Genetic Testing Testicular feminization Gynecology Breast development business.industry lcsh:R General Medicine Androgen-Insensitivity Syndrome medicine.disease 3. Good health Androgen receptor medicine.anatomical_structure primary amenorrhea Receptors Androgen Karyotyping Vagina Androgen insensitivity syndrome Female business |
| Zdroj: | Srpski Arhiv za Celokupno Lekarstvo, Vol 143, Iss 3-4, Pp 214-218 (2015) Srpski arhiv za celokupno lekarstvo (2015) 143(3-4):214-218 |
| ISSN: | 0370-8179 |
| Popis: | Introduction. Androgen insensitivity syndrome (AIS) belongs to disorders of sex development, resulting from complete or partial resistance to the biological actions of androgens in persons who are genetically males (XY) with normally developed testes and age-appropriate for males of serum testosterone concentration. Case Outline. A 21-year-old female patient was admitted at our Clinic further evaluation and treatment of testicular feminization syndrome, which was diagnosed at the age of 16 years. The patient had never menstruated. On physical examination, her external genitalia and breast development appeared as completely normal feminine structures but pubic and axillary hair was absent. Cytogenetic analysis showed a 46 XY karyotype. The values of sex hormones were as in adult males. The multisliced computed tomography (MSCT) showed structures on both sides of the pelvic region, suggestive of testes. Bilateral orchiectomy was performed. Hormone replacement therapy was prescribed after gonadectomy. Vaginal dilatation was advised to avoid dyspareunia. Conclusion. The diagnosis of complete androgen insensitivity is based on clinical findigs, hormonal analysis karyotype, visualization methods and genetic analysis. Bilateral gonadectomy is generally recommended in early adulthood to avoid the risk of testicular malignancy. Vaginal length may be short requiring dilatation in an effort to avoid dyspareunia. Vaginal surgery is rarely indicated for the creation of a functional vagina. [Projekat Ministarstva nauke Republike Srbije, br. 175067] |
| Databáze: | OpenAIRE |
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