Peptide-based strategies for enhanced cell uptake, transcellular transport, and circulation: Mechanisms and challenges
| Autor: | Kalina Hristova, Luisa M. Russell, Alexander Komin, Peter C. Searson |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell Pharmaceutical Science Peptide Cell-Penetrating Peptides 02 engineering and technology Computational biology Gene delivery Biology Pharmacology Genetic therapy 03 medical and health sciences Drug Delivery Systems Immune system medicine Animals Humans chemistry.chemical_classification Genetic Therapy 021001 nanoscience & nanotechnology 030104 developmental biology medicine.anatomical_structure Pharmaceutical Preparations chemistry Transcytosis Paracellular transport Drug delivery Peptides 0210 nano-technology |
| Zdroj: | Advanced Drug Delivery Reviews. :52-64 |
| ISSN: | 0169-409X |
| DOI: | 10.1016/j.addr.2016.06.002 |
| Popis: | Peptides are emerging as a new tool in drug and gene delivery. Peptide-drug conjugates and peptide-modified drug delivery systems provide new opportunities to avoid macrophage recognition and subsequent phagocytosis, cross endothelial and epithelial barriers, and enter the cytoplasm of target cells. Peptides are relatively small, low-cost, and are stable in a wide range of biological conditions. In this review, we summarize recent work in designing peptides to enhance penetration of biological barriers, increase cell uptake, and avoid the immune system. We highlight recent successes and contradictory results, and outline common emerging concepts and design rules. The development of sequence-structure-function relationships and standard protocols for benchmarking will be a key to progress in the field. |
| Databáze: | OpenAIRE |
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