Apparent prevention of neural tube defects by periconceptional vitamin supplementation*
| Autor: | A P Read, R W Smithells, S Sheppard, MaryJ. Seller, Rodney Harris, D.W. Fielding, N C Nevin, C J Schorah |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Epidemiology Rickets Prenatal care Pregnancy Internal medicine Vitamin D and neurology medicine Humans Neural Tube Defects Vitamin B12 Vitamin supplementation Neural tube defect business.industry Obstetrics Infant Newborn Neural tube Obstetrics and Gynecology Prenatal Care Vitamins General Medicine Prognosis Pyridoxine medicine.disease Parity Endocrinology medicine.anatomical_structure Social Class Fertilization Pediatrics Perinatology and Child Health Female business Follow-Up Studies Maternal Age Research Article medicine.drug |
| Zdroj: | International Journal of Epidemiology. 40:1146-1154 |
| ISSN: | 1464-3685 0300-5771 |
| DOI: | 10.1093/ije/dyr143 |
| Popis: | An earlier preliminary paper is expanded. Women who had given birth to one or more infants with a neural tube defect were recruited into a trial of per conceptional vitamin supplementation. Two hundred mothers attending five centres were fully supplemented (FS), 50 were partially supplemented (PS), and 300 were unsupplemented (US). Neural tube defect recurrences in the study pregnancies were 1 (0.5%), in FS, none in PS, and 13 (4%) in US mothers. The difference in outcome between FS and US mothers is significant. The most likely explanation is that supplementation has prevented some neural tube defects, but further studies are needed. |
| Databáze: | OpenAIRE |
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