Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer

Autor:	Charles A. Omer, Tracy L. Deegan, Minwei Ye, Les A. Dakin, Paul Lyne, Maureen Hattersley, Donald J. Cook, Xiaolan Zheng, Stephanos Ioannidis, Brian Aquila, Geraldine Bebernitz, Scott David
Rok vydání:	2008
Předmět:	medicine.drug_class Stereochemistry Clinical Biochemistry Mice Nude Pharmaceutical Science Antineoplastic Agents Receptor Macrophage Colony-Stimulating Factor Carboxamide Biochemistry Chemical synthesis Mice chemistry.chemical_compound In vivo Neoplasms Drug Discovery medicine Animals Humans Thiazole Molecular Biology chemistry.chemical_classification Kinase Chemistry Organic Chemistry Cancer 3T3 Cells medicine.disease Amides In vitro Rats Thiazoles Enzyme Molecular Medicine Female
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 18:4794-4797
ISSN:	0960-894X
Popis:	The bisamide class of kinase inhibitors was identified as being active against CSF-1R. The synthesis and SAR of pyridyl and thiazolyl bisamides are reported, along with the pharmacokinetic properties and in vivo activity of selected examples.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840dc35ec4d62a9f6566171915cb9740 https://doi.org/10.1016/j.bmcl.2008.07.093 Zobrazit plný text záznamu Full Text from ScienceDirect