Dosimetric Evaluation of a Simple Planning Technique for Improving Intensity-Modulated Radiotherapy for Nasopharyngeal Cancer
| Autor: | Michael Lok-Man Cheung, Mei Li, Wen-Jia Xie, Liang-Xi Xie, Bao-Tian Huang, Jia-Yang Lu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_treatment Science Nasopharyngeal neoplasm Planning target volume Young Adult Medicine Humans Radiometry Nasopharyngeal cancer Aged Aged 80 and over Multidisciplinary Nasopharyngeal Carcinoma Cold spot business.industry Radiotherapy Planning Computer-Assisted Carcinoma Nasopharyngeal Neoplasms Radiotherapy Dosage Planning Techniques Middle Aged Conformity index Target dose Radiation therapy Female Intensity modulated radiotherapy Radiotherapy Intensity-Modulated Nuclear medicine business Tomography X-Ray Computed Research Article |
| Zdroj: | PLoS ONE, Vol 10, Iss 7, p e0129461 (2015) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | PurposeTo evaluate the dosimetric outcomes of a simple planning technique for improving intensity-modulated radiotherapy (IMRT) for nasopharyngeal cancer (NPC).MethodsFor 39 NPC cases, generally acceptable original plans were generated and were improved by the two planning techniques, respectively: (1) a basal-dose-compensation (BDC) technique, in which the treatment plans were re-optimized based on the original plans; (2) a local-dose-control (LDC) technique, in which the original plans were re-optimized with constraints for hot and cold spots. The BDC, original, and LDC plans were then compared regarding homogeneity index (HI) and conformity index (CI) of planning target volumes (PTVs), organ-at-risk (OAR) sparing and monitor units (MUs) per fraction. The whole planning times were also compared between the BDC and LDC plans.ResultsThe BDC plans had superior HIs / CIs, by 13-24% / 3-243%, respectively, over the original plans. Compared to the LDC plans, the BDC plans provided better HIs only for PTVnx (the PTV of nasopharyngeal primary tumor) by 11% and better CIs for all PTVs by 2-134%. The BDC technique spared most OARs, by 1-9%. The average MUs of the BDC, original, and LDC plans were 2149, 2068 and 2179, respectively. The average whole planning times were 48 and 69 minutes for the BDC and LDC plans, respectively.ConclusionsFor the IMRT of nasopharyngeal cancer, the BDC planning technique can improve target dose homogeneity, conformity and OAR sparing, with better planning efficiency. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|