Cell response kinetics: The phenomenon of supercooperativity in aggregation of human platelets
| Autor: | Dimitry E. Yershov, P. V. Vrzheshch, Alexander V. Tatarintsev, S.D. Varfolomeyev |
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| Rok vydání: | 1992 |
| Předmět: |
Agonist
Epinephrine Platelet Aggregation Stereochemistry medicine.drug_class Kinetics Cooperativity chemistry.chemical_compound symbols.namesake Cell–cell interaction medicine Humans Prostaglandins H Platelet Platelet Activating Factor Calcimycin Hill differential equation Arachidonic Acid Thimerosal Hematology Prostaglandin Endoperoxides Synthetic Adenosine Diphosphate chemistry 15-Hydroxy-11 alpha 9 alpha-(epoxymethano)prosta-5 13-dienoic Acid symbols Prostaglandin H2 Tetradecanoylphorbol Acetate Arachidonic acid Signal transduction |
| Zdroj: | Thrombosis Research. 66:537-547 |
| ISSN: | 0049-3848 |
| DOI: | 10.1016/0049-3848(92)90308-w |
| Popis: | Concentration - response relationships of human platelet aggregation rates were analyzed for a variety of agonists and inhibitors. Their approximation by the Hill equation showed that the values of the Hill coefficient (h) were agonist-dependent and increased as follows: h ADP = h L-EPINEPHRINE = h PAF = h PGH2 = h U46619 h PMA h A23187 h MERTHIOLATE = h ARACHIDONATE . The results were interpreted in terms of a model assuming varying degrees of cooperativity for each step of signal transduction involved in platelet aggregation. Super-high values of h (>30) obtained with arachidonate and merthiolate, as well as in the case of inhibition of an arachidonate-induced response by indomethacin and PTA 2 , suggested that at least one region of signal transduction pathway leading to aggregation exhibited supercooperative properties. |
| Databáze: | OpenAIRE |
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