Effect of Age on the Relationship between Gastric Cancer andHelicobacter pylori
| Autor: | Shogo Kikuchi, Toshiro Konishi, Hideaki Watanabe, Kiyoshi Mori, Yutaka Inaba, Reiji Otani, Haruyuki Anzai, Noboru Mizobuchi, Shinsuke Oura, Shunji Futagawa, Toshifusa Nakajima, Michiko Kurosawa, Ruriko Kaise, Hirokazu Nagawa, Naoyuki Okamoto, Tosiya Sato, Osamu Kobayashi, Tatsuo Yamazaki, Masahiro Kikuichi, Takuji Kubo, Osamu Wada, Oichiro Kobori |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Aging Cancer Research medicine.medical_specialty Spirillaceae medicine.disease_cause Gastroenterology Article Helicobacter Infections Age Risk Factors Seroepidemiologic Studies Stomach Neoplasms Internal medicine Odds Ratio medicine Gastric mucosa Humans Intestinal Cancer Aged Helicobacter pylori biology business.industry Early diffuse‐type cancer Stomach Age Factors Cancer Odds ratio Middle Aged biology.organism_classification medicine.disease medicine.anatomical_structure Oncology Female Gastric cancer Carcinogenesis business |
| Zdroj: | Japanese Journal of Cancer Research : Gann |
| ISSN: | 0910-5050 |
| Popis: | Helicobacter pylori is thought to be involved in the pathogenesis of gastric cancer, but the time point at which it produces its effects (critical time) is unknown. We measured the serum level of H. pylori antibody in 787 gastric cancer patients and 1007 controls aged 20 to 69. Odds ratios for different gastric cancer types and stages were determined for each 10-year age class. The overall odds ratio for gastric cancer decreased with age, being 7.0 for those aged 20 - 29, 14.5 for those aged 30 - 39, 9.1 for those aged 40 - 49, 3.5 for those aged 50 - 59, and 1.5 for those aged 60 - 69 (trend in odds ratios: P < 0.01). However, there was no such age-dependent trend for early diffuse-type cancer; the odds ratios were 12.6, 4.0, 7.2, 6.5, and 18.5 respectively (P = 0.29). Early cancer tended to show higher seroprevalence than advanced cancer, especially in older subjects. No significant difference in seroprevalence was observed between diffuse and intestinal cancers within each age-class. Seroreversion must have occurred in the time interval between the critical time and the diagnosis of the cancer, especially in older patients. The age-dependent relationship between H. pylori and gastric cancer may be due to seroreversion, which itself may be independent of age. This age-independence indicates that prolonged exposure to H. pylori does not increase the magnitude of its influence on gastric carcinogenesis. Possible mechanisms through which H. pylori exerts pathogenic effects are continuous inflammation in adulthood and / or irreversible damage to gastric mucosa in childhood or the teenage years. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text