Potential of Krebs von den Lungen-6 as a predictor of relapse in interstitial pneumonia with anti-aminoacyl tRNA synthetase antibodies-positive dermatomyositis

Autor:	Tohru Takeuchi, Takuya Kotani, Shigeki Makino, Takaaki Ishida, Hiroshi Fujiwara, Kentaro Isoda, Takeshi Shoda, Junichi Konma, Shigeki Arawaka, Kenichiro Hata, Kenichiro Otani
Rok vydání:	2018
Předmět:	Adult Male Pulmonary and Respiratory Medicine medicine.medical_specialty Gastroenterology Antibodies Dermatomyositis Amino Acyl-tRNA Synthetases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Recurrence Internal medicine medicine Humans Immunology and Allergy In patient Interstitial pneumonia 030212 general & internal medicine Genetics (clinical) Aged Retrospective Studies 030203 arthritis & rheumatology biology business.industry Aminoacyl tRNA synthetase Mucin-1 Retrospective cohort study Middle Aged medicine.disease chemistry Area Under Curve biology.protein Female Antibody Lung Diseases Interstitial business Area under the roc curve Biomarkers After treatment
Zdroj:	The Clinical Respiratory Journal. 12:2235-2241
ISSN:	1752-6981
Popis:	OBJECTIVE To identify a predictor of relapse in interstitial pneumonia (IP) in patients with anti-aminoacyl tRNA synthetase antibodies-positive dermatomyositis (ARS-DMIP). METHODS This retrospective cohort study comprised 27 ARS-DMIP patients. We compared clinical and laboratory findings between the relapse and non-relapse groups during 2 years after treatment initiation to find predictors of relapse in IP. Candidate predictors were further assessed by analysing the relationship with the relapse of IP. RESULTS One patient with ARS-DMIP died. About 7 (26.9%) of the remaining 26 patients with ARS-DMIP had a relapse of IP. We found that the levels of serum Krebs von den Lungen-6 (KL-6) in the relapse group were significantly higher than those in the non-relapse group at the time points before treatment (P = .046) and after treatments, including 6 (P = .004), 12 (P = .013), 18 (P = .003) and 24 months (P
Databáze:	OpenAIRE
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