Both four-dimensional computed tomography and four-dimensional cone beam computed tomography under-predict lung target motion during radiotherapy
| Autor: | Dasantha Jayamanne, Nicholas Hardcastle, Chun-Chien Shieh, Paul J. Keall, Elisabeth Steiner, Thomas Eade, Ricky O'Brien, Jeremy T. Booth, Adam Briggs, Vincent Caillet, Kathryn Szymura |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cone beam computed tomography
Lung Neoplasms medicine.medical_treatment Motion (geometry) SABR volatility model Radiosurgery 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Treatment targets motion management Predictive Value of Tests medicine Humans Radiology Nuclear Medicine and imaging Computer Simulation Four-Dimensional Computed Tomography Lung Physics business.industry Radiotherapy Planning Computer-Assisted Centroid Hematology Cone-Beam Computed Tomography Radiation therapy Amplitude Oncology 030220 oncology & carcinogenesis Respiratory Mechanics Nuclear medicine business Algorithms |
| Popis: | BACKGROUND AND PURPOSE: To test the hypothesis that 4DCT and 4DCBCT-measured target motion ranges predict target motion ranges during lung cancer SABR. MATERIALS AND METHODS: Ten lung SABR patients were implanted with Calypso beacons. 4DCBCT was reconstructed for 29 fractions (1-4fx/patient) from a 1 min CBCT scan. The beacon centroid motion segmented for all 4DCT and 4DCBCT bins was compared with the real-time imaging and treatment beacon centroid ("target") motion range (4SDs) for each fraction. We tested the hypotheses that (1) 4DCT and 4CBCT predict treatment motion range and (2) there is no difference between 4DCT and 4DCBCT for predicting treatment motion range. Phase-wise root-mean-square errors (RMSEs) between imaging and treatment motion and reconstructed motion (4DCT, 4DCBCT) were calculated. Relationships between motion ranges in 4DCT and 4DCBCT and imaging and treatment motion ranges were investigated for the superior-inferior (SI), left-right (LR) and anterior-posterior (AP) directions. Baseline drifts and amplitude variability were investigated as potential factors leading to motion misrepresentation. RESULTS: SI 4DCT, 4DCBCT, imaging and treatment motion ranges were 6.3 ± 3.6 mm, 7.1 ± 4.5 mm, 11.1 ± 7.5 mm and 10.9 ± 6.9 mm, respectively. Similar 4DCT and 4DCBCT under-predictions were observed in the LR and AP directions. Hypothesis (1) was rejected (p |
| Databáze: | OpenAIRE |
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