Tetra-chloro-(bis-(3,5-dimethylpyrazolyl)methane)gold(III) chloride: An HIV-1 reverse transcriptase and protease inhibitor
| Autor: | Ilia A. Guzei, Pascaline Nanga Fonteh, Frankline K. Keter, James Darkwa, Debra Meyer |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Stereochemistry
medicine.medical_treatment Protonation Crystallography X-Ray Biochemistry Chloride Gold(III) chloride Inorganic Chemistry Acetic acid chemistry.chemical_compound HIV Protease medicine Humans Cells Cultured chemistry.chemical_classification Protease Molecular Structure biology Ligand HIV Protease Inhibitors HIV Reverse Transcriptase Enzyme assay Enzyme chemistry HIV-1 biology.protein Reverse Transcriptase Inhibitors Organogold Compounds medicine.drug |
| Zdroj: | Journal of Inorganic Biochemistry. 103:190-194 |
| ISSN: | 0162-0134 |
| Popis: | The title compound ([3,5-Me(2)bpzaH(2)][AuCl(4)]Cl, 1) (Me(2)bpza=bis(3,5-dimethylpyrazolyl)acetic acid), was prepared by reacting H[AuCl(4)] with 3,5-Me(2)bpza; and spectroscopically and structurally characterized. In the solid state structure of 1, the pyrazolyl ligand is doubly protonated to form two strong charge assisted hydrogen bonds of the type N(+)Hcdots, three dots, centeredCl(-) with the single chloride anion whilst the [AuCl(4)](-) anion remains discrete. The anti-HIV-1 activity of 1 was determined by a colorimetric direct enzyme reverse transcriptase (RT) assay and a fluorogenic protease (PR) assay. Compound 1 significantly (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect