Neuroprotective effects of a specific multi-nutrient intervention against Aβ42-induced toxicity in rats
| Autor: | Martijn C. de Wilde, Patrick Joseph Gerardus Hendrikus Kamphuis, Laus M. Broersen, Almar A.M. Kuipers, Botond Penke, Eline Marleen Van Der Beek |
|---|---|
| Přispěvatelé: | Center for Liver, Digestive and Metabolic Diseases (CLDM), Reproductive Origins of Adult Health and Disease (ROAHD) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Biology Neuroprotection Rats Sprague-Dawley chemistry.chemical_compound Alzheimer Disease Phosphatidylcholine Internal medicine Vesicular acetylcholine transporter medicine Choline Animals Peptide Fragments/antagonists & inhibitors Alzheimer Disease/etiology Amyloid beta-Peptides/antagonists & inhibitors chemistry.chemical_classification Amyloid beta-Peptides General Neuroscience General Medicine Fortified Choline acetyltransferase Peptide Fragments Rats Psychiatry and Mental health Clinical Psychology Endocrinology Neuroprotective Agents Neuroprotective Agents/administration & dosage chemistry Food Toxicity Food Fortified Cholinergic Sprague-Dawley Geriatrics and Gerontology Polyunsaturated fatty acid |
| Zdroj: | Journal of Alzheimer’s Disease, 27(2), 327-39. IOS Press |
| ISSN: | 1875-8908 |
| Popis: | Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most common cause of dementia in the elderly. Substantial evidence suggests a role for nutrition in the management of AD and especially suggests that interventions with combinations of nutrients are more effective than single-nutrient interventions. The specific multi-nutrient combination Fortasyn™Connect (FC), shown to improve memory in AD, provides phosphatide precursors and cofactors and is designed to stimulate the formation of phospholipids, neuronal membranes, and synapses. The composition comprises nucleotides, omega-3 polyunsaturated fatty acids (n3 PUFA), choline, B-vitamins, phospholipids, and antioxidants. The current study explored the protective properties of FC in a membrane toxicity model of AD, the amyloid-β 1-42 (Aβ42) infused rat, which shows reduced exploratory behavior in an Open Field and impaired cholinergic functioning. To this end, rats were fed an FC enriched diet or a control diet and five weeks later infused with vehicle or Aβ42 into the lateral ventricle. Ten weeks post-infusion Aβ42-rats fed the FC diet showed increased membrane n3 PUFA and phosphatidylcholine content while they did not show the reductions in exploratory behavior or in choline acetyltransferase (ChAT) and vesicular acetylcholine transporter (VAChT) immunoreactivity that were seen in Aβ42-rats fed the control diet. We conclude that FC protects the cholinergic system against Aβ42-induced toxicity and speculate that the effects of FC on membrane formation and composition might be supportive for this protective effect. Based on these data a long-term intervention study was started in the prodromal stages of AD (NTR1705, LipiDiDiet, EU FP7). |
| Databáze: | OpenAIRE |
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