Marine Algae Incorporated Polylactide Acid Patch: Novel Candidate for Targeting Osteosarcoma Cells without Impairing the Osteoblastic Proliferation
| Autor: | Hendrik Naujokat, Theresa Kohlhaas, Mustafa Ayna, Salih Veziroglu, Selin Sayin, Yahya Açil, Fatih Karayürek, Aydin Gülses, Yogendra Kumar Mishra, Oral Cenk Aktas, Franz Faupel, Jacek Fiutowski, Eyup Ilker Saygili, Jörg Wiltfang |
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| Přispěvatelé: | Deniz Bilimleri ve Teknolojisi Fakültesi -- Deniz Teknolojileri Bölümü, Sayın, Selin |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Scaffold
sarcoma Polymers and Plastics Composite number Butylene Glycol Adipic Acid Polyester Sargassum vulgare In-vitro Bionole Osteosarcoma cells Cell proliferation Infection transmission Composites chemistry.chemical_classification biology Chemistry Osteoblast Solvent casting method Sarcoma Polymer Adhesion Poly(Lactide) Clinical application Cell biology Vivo medicine.anatomical_structure Membrane Composite patch Osteosarcoma Pla Collagen Algae Polyesters Polymer Science Material characterizations Article lcsh:QD241-441 lcsh:Organic chemistry medicine Bone Scaffolds Antiproliferative effect Marine algae sargassum vulgare Anticoagulant Stress intensity factors Composite membranes General Chemistry medicine.disease biology.organism_classification Blending Costs Sulfated polysaccharide Cytology Synthetic polymers |
| Zdroj: | Fiutowski, J, Mishra, Y K, Veziroglu, S, Ayna, M, Kohlhaas, T, Sayin, S, Karayürek, F, Naujokat, H, Saygili, E İ, Açil, Y, Wiltfang, J, Faupel, F, Aktas, O C & Gülses, A 2021, ' Marine algae incorporated polylactide acid patch : novel candidate for targeting osteosarcoma cells without impairing the osteoblastic proliferation ', Polymers, vol. 13, no. 6, 847 . https://doi.org/10.3390/polym13060847 Polymers, Vol 13, Iss 847, p 847 (2021) Polymers Volume 13 Issue 6 |
| DOI: | 10.3390/polym13060847 |
| Popis: | Biodegradable collagen-based materials have been preferred as scaffolds and grafts for diverse clinical applications in density and orthopedy. Besides the advantages of using such bio-originated materials, the use of collagen matrices increases the risk of infection transmission through the cells or the tissues of the graft/scaffold. In addition, such collagen-based solutions are not counted as economically feasible approaches due to their high production cost. In recent years, incorporation of marine algae in synthetic polymers has been considered as an alternative method for preparation grafts/scaffolds since they represent abundant and cheap source of potential biopolymers. Current work aims to propose a novel composite patch prepared by blending Sargassum vulgare powders (SVP) to polylactide (PLA) as an alternative to the porcine-derived membranes. SVP-PLA composite patches were produced by using a modified solvent casting method. Following detailed material characterization to assess the cytocompatibility, human osteoblasts (HOBs) and osteosarcoma cells (SaOS-2) were seeded on neat PLA and SVP-PLA patches. MTT and BrdU assays indicated a greater cytocompatibility and higher proliferation for HOBs cultured on SVP-PLA composite than for those cultured on neat PLA. SaOS-2 cells cultured on SVP-PLA exhibited a significant decrease in cell proliferation. The composite patch described herein exhibits an antiproliferative effect against SaOS-2 cells without impairing HOBs’ adhesion and proliferation. |
| Databáze: | OpenAIRE |
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