Update on Ocular Myasthenia Gravis
| Autor: | Meabh O'Hare, Christopher T. Doughty |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Diplopia
medicine.medical_specialty medicine.diagnostic_test business.industry Ocular myasthenia Fatigable weakness Physical examination 030204 cardiovascular system & hematology medicine.disease Extraocular muscles Dermatology Myasthenia gravis Review article 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Neurology Ptosis Myasthenia Gravis medicine Humans Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Seminars in Neurology. 39:749-760 |
| ISSN: | 1098-9021 0271-8235 |
| DOI: | 10.1055/s-0039-1700527 |
| Popis: | Myasthenia gravis is an antibody-mediated autoimmune disorder of the post-synaptic neuromuscular junction resulting in fluctuating, fatigable weakness. Most patients first present with extraocular symptoms (diplopia and/or ptosis), and in 15% of cases symptoms will remain restricted to only the extraocular muscles (ocular myasthenia gravis [OMG]). The history and clinical examination are of the utmost importance in correctly identifying OMG patients, as supportive serologic or electrodiagnostic studies are frequently nondiagnostic. In this review, we outline a diagnostic approach to OMG (focusing on key clinical features), discuss therapeutic options, and highlight recent developments in the understanding of OMG. |
| Databáze: | OpenAIRE |
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