Behavioral and molecular effects of prenatal continuous light exposure in the adult rat
| Autor: | Leon Zagrean, Diana Le Duc, Diana Maria Chiţimuș, Ana-Maria Zagrean, Vlad Zeca, Andreea Letiţia Arsene, Adrian Eugen Roșca, Alina Crenguţa Nicolae, Cristina Manuela Drăgoi, Torsten Schöneberg, Suzana Elena Voiculescu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Serotonin medicine.medical_specialty Light Offspring Anxiety Biology medicine.disease_cause Amygdala Melatonin 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine medicine Animals Circadian rhythm Rats Wistar Maze Learning Prefrontal cortex Molecular Biology Serotonin Plasma Membrane Transport Proteins Behavior Animal General Neuroscience Brain Nuclear Receptor Subfamily 1 Group F Member 1 medicine.disease Circadian Rhythm Rats Oxidative Stress Memory Short-Term 030104 developmental biology Endocrinology medicine.anatomical_structure Animals Newborn Prenatal Exposure Delayed Effects Female Neurology (clinical) 030217 neurology & neurosurgery Oxidative stress Developmental Biology medicine.drug |
| Zdroj: | Brain Research. 1650:51-59 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/j.brainres.2016.08.031 |
| Popis: | Disruption of the maternal environment during pregnancy leads to behavioral changes and diseases in the adult offspring. To explore the influence of prenatal continuous light exposure (PCLE) on the adult offspring, we exposed pregnant Wistar rats to constant light during late gestation. Adult PCLE offspring showed an anxiety-like behavior and impairment of short-term memory in different tests. Measurements in the whole brain homogenates from newborn and adult offspring indicated decreased melatonin and serotonin levels and increased reactive oxygen species level in PCLE offspring. Further, we determined melatonin-, serotonin-, oxidative stress-, apoptosis-, and circadian system-related genes expression in different brain areas of adult offspring. The serotonin reuptaker Slc6a4 displayed a decreased expression in the prefrontal cortex of PCLE group. The circadian rhythm-related gene Rora was upregulated in the amygdala of PCLE offspring. Our results point to adverse behavioral effects of PCLE on adult offspring, involving serotonin and melatonin signaling dysregulation, increased chronic oxidative stress, and altered gene expression. |
| Databáze: | OpenAIRE |
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