Immunological basis in the pathogenesis of intrahepatic cholestasis of pregnancy
| Autor: | Oormila Kovilam, Devendra K. Agrawal, Spencer P Larson |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Immunology Bioinformatics Gastroenterology Article Pathogenesis 03 medical and health sciences Th2 Cells Immune system Cholestasis Pregnancy Immunity Internal medicine medicine Animals Humans Immunology and Allergy Th1-Th2 Balance business.industry Ursodeoxycholic Acid medicine.disease Ursodeoxycholic acid Pregnancy Complications 030104 developmental biology Liver Female sense organs business Cholestasis of pregnancy medicine.drug |
| Zdroj: | Expert Review of Clinical Immunology. 12:39-48 |
| ISSN: | 1744-8409 1744-666X |
| Popis: | Intrahepatic cholestasis of pregnancy poses a great risk to both maternal and fetal health. Despite extensive research, much of the pathogenesis of this disorder is unknown. The increase in bile acids observed in patients with intrahepatic cholestasis of pregnancy has been noted to cause a change in the immune system from the normally mediated TH2 response to one that is more oriented towards TH1. In this literature review, we have critically reviewed the current literature regarding the changes in the immune system and the potential effects of immunological changes in the management of the patient. The current treatment, ursodeoxycholic acid, is also discussed along with potential combination therapies and future directions for research. |
| Databáze: | OpenAIRE |
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