Current Issues and Perspectives in Patients with Possible Sepsis at Emergency Departments
| Autor: | Francesca Castellaneta, Ioannis Alexandros Charitos, Donato D'Agostino, Skender Topi |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Resuscitation Review Biochemistry Microbiology antibiotics Sepsis sepsis 03 medical and health sciences 0302 clinical medicine medicine Pharmacology (medical) In patient sepsis management 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics Intensive care medicine SOFA score laboratory diagnosis Septic shock business.industry lcsh:RM1-950 medicine.disease Organ damage Infectious Diseases lcsh:Therapeutics. Pharmacology probiotics Supportive psychotherapy plant extract medicine.symptom business 030215 immunology Altered level of consciousness |
| Zdroj: | Antibiotics Antibiotics, Vol 8, Iss 2, p 56 (2019) |
| ISSN: | 2079-6382 |
| Popis: | In the area of Emergency Room (ER), many patients present criteria compatible with a SIRS, but only some of them have an associated infection. The new definition of sepsis by the European Society of Intensive Care Medicine and the Society of Critical Care Medicine (2016), revolutionizes precedent criteria, overcoming the concept of SIRS and clearly distinguishing the infection with the patient’s physiological response from the symptoms of sepsis. Another fundamental change concerns the recognition method: The use of SOFA (Sequential-Sepsis Related-Organ Failure Assessment Score) as reference score for organ damage assessment. Also, the use of the qSOFA is based on the use of three objective parameters: Altered level of consciousness (GCS 18 mg/dL in despite of an adequate volume resuscitation. Then, patient first management is mainly based on: (1) Recognition of the potentially septic patient (sepsis protocol-qSOFA); (2) Laboratory investigations; (3) Empirical antibiotic therapy in patients with sepsis and septic shock. With this in mind, the authors discuss the most important aspects of the sepsis in both adults and infants, and also consider the possible treatment according current guidelines. In addition, the possible role of some nutraceuticals as supportive therapy in septic patient is also discussed. |
| Databáze: | OpenAIRE |
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