Brief Report: Circulating Markers of Immunologic Activity Reflect Adiposity in Persons With HIV on Antiretroviral Therapy
| Autor: | Bryan E. Shepherd, John R. Koethe, Briana D. Furch, Todd Hulgan, Cathy A. Jenkins, Cindy C. Hager, Louise Barnett, Rita M. Smith, Spyros A. Kalams, Jordan E. Lake |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Oncology medicine.medical_specialty Efavirenz Tenofovir Anti-HIV Agents Human immunodeficiency virus (HIV) Adipose tissue HIV Infections medicine.disease_cause Emtricitabine Article 03 medical and health sciences chemistry.chemical_compound Absorptiometry Photon 0302 clinical medicine immune system diseases Internal medicine medicine Humans Pharmacology (medical) 030212 general & internal medicine Adiposity business.industry virus diseases Middle Aged medicine.disease Antiretroviral therapy Obesity CD4 Lymphocyte Count 030104 developmental biology Infectious Diseases chemistry Female Inflammatory biomarker business Biomarkers medicine.drug |
| Zdroj: | JAIDS Journal of Acquired Immune Deficiency Syndromes. 79:135-140 |
| ISSN: | 1525-4135 |
| DOI: | 10.1097/qai.0000000000001768 |
| Popis: | BACKGROUND: Obesity alters adipose tissue immunology, and these changes may be reflected in circulating soluble inflammatory biomarker and T cell subset profiles measured in HIV research studies. METHODS: We recruited 70 adults with HIV (50% obese) on efavirenz, tenofovir, and emtricitabine, virologic suppression for >2 years, and no rheumatologic or other known inflammatory conditions. We measured fasting plasma levels of several markers of innate immunity and major CD4(+) and CD8(+) T cell subsets. We assessed relationships between measurements of total adiposity (body mass index [BMI], DEXA fat mass index [FMI], and plasma leptin) and the immunologic parameters using covariate-adjusted Spearman’s rank correlations. RESULTS: The cohort was 43% female, 54% non-white, and median age was 45 years. Higher BMI, FMI and plasma leptin were consistently associated with higher C-reactive protein, serum amyloid A, and interleukin (IL)-6 (p |
| Databáze: | OpenAIRE |
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