Relationship between baseline white blood cell count and renal and hepatic function in older patients with acute myeloid leukemia
| Autor: | Agnieszka Wierzbowska, Hagop M. Kantarjian, Grzegorz Mazur, Erhan Berrak, Jacques Delaunay, Mark M. Jones, Mark D. Minden |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
medicine.medical_specialty ECOG PS Eastern Cooperative Oncology Group Performance Status BUN blood urea nitrogen Decitabine AST aspartate aminotransferase Gastroenterology lcsh:RC254-282 Article CRi complete response with incomplete blood count recovery hemic and lymphatic diseases Internal medicine White blood cell ALT alanine aminotransferase Post-hoc analysis medicine Blood urea nitrogen AML acute myeloid leukemia Acute myeloid leukemia Leukemia SC supportive care business.industry PR partial remission Myeloid leukemia Hematology medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Prognosis medicine.anatomical_structure Oncology Immunology CR complete response Cytarabine business medicine.drug French–American–British classification FAB French–American–British classification WBC white blood cell |
| Zdroj: | Leukemia Research Reports Leukemia Research Reports, Vol 3, Iss 1, Pp 17-20 (2014) |
| ISSN: | 2213-0489 |
| DOI: | 10.1016/j.lrr.2013.12.001 |
| Popis: | Background: In a phase III trial, older patients with acute myeloid leukemia (N=485) received decitabine or treatment choice (supportive care or cytarabine). This post hoc analysis examined whether baseline renal and hepatic function and white blood cell (WBC) counts predicted response. Methods: Baseline WBCs and renal and liver function markers were tabulated for responders/nonresponders. Results: Nonresponders had higher mean baseline creatinine (P=0.005). Creatinine data showed no significant between-group differences by treatment within responder category. Conclusions: No relationship was found between baseline WBCs or hepatic function and response. Higher baseline creatinine in nonresponders may not be clinically relevant. |
| Databáze: | OpenAIRE |
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