Treating chronic urticaria refractory to H1-antihistamines in Russia: data from the AWARE study

Autor: Inna Danilycheva, Alexander Emelyanov, Raisa Meshkova, Olga Ukhanova, Azat Abdrakhmanov, Loliana Litvin
Rok vydání: 2020
Předmět:
Zdroj: Postepy dermatologii i alergologii. 39(3)
ISSN: 1642-395X
Popis: Data on burden and treatment outcomes of chronic spontaneous urticaria (CSU) in Russia are limited. Poor adherence to recommended treatments can lead to suboptimal management of CSU patients.To understand disease burden, treatment algorithms, and outcomes of CSU in the Russian cohort of the AWARE study.AWARE was a global prospective, non-interventional study of chronic urticaria in the real-world setting. Adult patients with H1-antihistamines (H1AH)-refractory CSU for ≥ 2 months were included. Disease characteristics, quality of life (QoL), healthcare resource utilisation (HRU), and pharmacological treatments were observed during the 2-year study period.Of the 135 patients enrolled from Russia, 121 completed the study. Pre-baseline, ~37% of patients were managed with non-recommended treatments (33% treated with sedative H1AH; 4% with other non-recommended treatments) and 28.2% of patients were not treated for CSU. There was a reduction in the use of sedative H1AH during the study (0.9% of patients treated with sedative H1AHs at Year 2). Decreased disease activity was seen as early as 3 months and continued to improve over 2 years (Urticaria Activity Score over 7 days (UAS7): 20.2 at baseline (The burden of CSU in Russia is high, contributing to increased HRU. Guideline-recommended treatments and systematic escalation of therapy to achieve complete symptom control can improve management of patients with CSU.
Databáze: OpenAIRE