Higher-order sensorimotor circuit of the brain's global network supports human consciousness

Autor: Georg Northoff, Yihong Yang, Stuart Fogel, Pengmin Qin, Tanikawa Hiromi, Di Zang, Zengxin Qi, Xuchu Weng, Jun Zhang, Ying Mao, Jiaxing Tan, Changwei W. Wu, Zirui Huang, Emmanuel Stamatakis, Xuehai Wu, Sean Tanabe, Weijun Tang, Anthony G. Hudetz, Hang Wu
Rok vydání: 2021
Předmět:
Adult
Male
Consciousness
Cognitive Neuroscience
media_common.quotation_subject
Sleep
REM
Neurosciences. Biological psychiatry. Neuropsychiatry
Disorders of consciousness
Article
050105 experimental psychology
Young Adult
03 medical and health sciences
0302 clinical medicine
Level of consciousness
Supramarginal gyrus
medicine
Humans
Anesthesia
0501 psychology and cognitive sciences
Wakefulness
media_common
Resting state fMRI
Supplementary motor area
05 social sciences
Minimally conscious state
Electroencephalography
medicine.disease
Magnetic Resonance Imaging
Inferior parietal lobule
medicine.anatomical_structure
Neurology
Degree centrality
Rapid eye movement sleep
Female
Sensorimotor Cortex
Nerve Net
Psychology
Higher-order sensorimotor circuit
Neuroscience
Anesthetics
Intravenous
030217 neurology & neurosurgery
RC321-571
Zdroj: Neuroimage
NeuroImage, Vol 231, Iss, Pp 117850-(2021)
ISSN: 1053-8119
Popis: Consciousness is a mental characteristic of the human mind, whose exact neural features remain unclear. We aimed to identify the critical nodes within the brain's global functional network that support consciousness. To that end, we collected a large fMRI resting state dataset with subjects in at least one of the following three consciousness states: preserved (including the healthy awake state, and patients with a brain injury history (BI) that is fully conscious), reduced (including the N1-sleep state, and minimally conscious state), and lost (including the N3-sleep state, anesthesia, and unresponsive wakefulness state). We also included a unique dataset of subjects in rapid eye movement sleep state (REM-sleep) to test for the presence of consciousness with minimum movements and sensory input. To identify critical nodes, i.e., hubs, within the brain's global functional network, we used a graph-theoretical measure of degree centrality conjoined with ROI-based functional connectivity. Using these methods, we identified various higher-order sensory and motor regions including the supplementary motor area, bilateral supramarginal gyrus (part of inferior parietal lobule), supragenual/dorsal anterior cingulate cortex, and left middle temporal gyrus, that could be important hubs whose degree centrality was significantly reduced when consciousness was reduced or absent. Additionally, we identified a sensorimotor circuit, in which the functional connectivity among these regions was significantly correlated with levels of consciousness across the different groups, and remained present in the REM-sleep group. Taken together, we demonstrated that regions forming a higher-order sensorimotor integration circuit are involved in supporting consciousness within the brain's global functional network. That offers novel and more mechanism-guided treatment targets for disorders of consciousness.
Databáze: OpenAIRE
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