Higher-order sensorimotor circuit of the brain's global network supports human consciousness
Autor: | Georg Northoff, Yihong Yang, Stuart Fogel, Pengmin Qin, Tanikawa Hiromi, Di Zang, Zengxin Qi, Xuchu Weng, Jun Zhang, Ying Mao, Jiaxing Tan, Changwei W. Wu, Zirui Huang, Emmanuel Stamatakis, Xuehai Wu, Sean Tanabe, Weijun Tang, Anthony G. Hudetz, Hang Wu |
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Rok vydání: | 2021 |
Předmět: |
Adult
Male Consciousness Cognitive Neuroscience media_common.quotation_subject Sleep REM Neurosciences. Biological psychiatry. Neuropsychiatry Disorders of consciousness Article 050105 experimental psychology Young Adult 03 medical and health sciences 0302 clinical medicine Level of consciousness Supramarginal gyrus medicine Humans Anesthesia 0501 psychology and cognitive sciences Wakefulness media_common Resting state fMRI Supplementary motor area 05 social sciences Minimally conscious state Electroencephalography medicine.disease Magnetic Resonance Imaging Inferior parietal lobule medicine.anatomical_structure Neurology Degree centrality Rapid eye movement sleep Female Sensorimotor Cortex Nerve Net Psychology Higher-order sensorimotor circuit Neuroscience Anesthetics Intravenous 030217 neurology & neurosurgery RC321-571 |
Zdroj: | Neuroimage NeuroImage, Vol 231, Iss, Pp 117850-(2021) |
ISSN: | 1053-8119 |
Popis: | Consciousness is a mental characteristic of the human mind, whose exact neural features remain unclear. We aimed to identify the critical nodes within the brain's global functional network that support consciousness. To that end, we collected a large fMRI resting state dataset with subjects in at least one of the following three consciousness states: preserved (including the healthy awake state, and patients with a brain injury history (BI) that is fully conscious), reduced (including the N1-sleep state, and minimally conscious state), and lost (including the N3-sleep state, anesthesia, and unresponsive wakefulness state). We also included a unique dataset of subjects in rapid eye movement sleep state (REM-sleep) to test for the presence of consciousness with minimum movements and sensory input. To identify critical nodes, i.e., hubs, within the brain's global functional network, we used a graph-theoretical measure of degree centrality conjoined with ROI-based functional connectivity. Using these methods, we identified various higher-order sensory and motor regions including the supplementary motor area, bilateral supramarginal gyrus (part of inferior parietal lobule), supragenual/dorsal anterior cingulate cortex, and left middle temporal gyrus, that could be important hubs whose degree centrality was significantly reduced when consciousness was reduced or absent. Additionally, we identified a sensorimotor circuit, in which the functional connectivity among these regions was significantly correlated with levels of consciousness across the different groups, and remained present in the REM-sleep group. Taken together, we demonstrated that regions forming a higher-order sensorimotor integration circuit are involved in supporting consciousness within the brain's global functional network. That offers novel and more mechanism-guided treatment targets for disorders of consciousness. |
Databáze: | OpenAIRE |
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