Reduction of serotonin transporters of patients with chronic fatigue syndrome
| Autor: | Shigeyuki Yamamoto, Hirotaka Onoe, Hirohiko Kuratsune, Hideo Tsukada, Etsuji Yoshikawa, Yasuyoshi Watanabe, Masao Iwase, Kouzi Yamaguti, Yasuomi Ouchi, Hidetoshi Takahashi |
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| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Central nervous system Nerve Tissue Proteins Serotonergic Gyrus Cinguli chemistry.chemical_compound Internal medicine medicine Chronic fatigue syndrome Humans Neurotransmitter Serotonin transporter Pain Measurement Serotonin Plasma Membrane Transport Proteins Brain Mapping Carbon Isotopes Fatigue Syndrome Chronic Membrane Glycoproteins biology General Neuroscience Membrane Transport Proteins Middle Aged Isoquinolines medicine.disease Magnetic Resonance Imaging Endocrinology medicine.anatomical_structure chemistry Case-Control Studies Positron-Emission Tomography biology.protein Female Serotonin Psychology McN5652 |
| Zdroj: | NeuroReport. 15:2571-2574 |
| ISSN: | 0959-4965 |
| Popis: | To assess the involvement of serotonin in the symptoms of chronic fatigue syndrome, we investigated the serotonergic neurotransmitter system of chronic fatigue syndrome patients by the positron emission tomography (PET). Here we show that the density of serotonin transporters (5-HTTs) in the brain, as determined by using a radiotracer, [C](+)McN5652, was significantly reduced in the rostral subdivision of the anterior cingulate as compared with that in normal volunteers. This subdivision is different from that in the dorsal anterior cingulate in which binding potential values of individual patient showed a weak negative correlation with self-reported pain score of the patients. Therefore, an alteration of serotonergic system in the rostral anterior cingulate plays a key role in pathophysiology of chronic fatigue syndrome. |
| Databáze: | OpenAIRE |
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