The value of lymph node dissection in hereditary medullary thyroid carcinoma: a retrospective, European, multicentre study
| Autor: | F. Bacourt, F. Limbert, B. Niederle, G. Gheri, H. F. A. Vasen, C. Proye, M. Berner, Andrea Frilling, H. Dralle, Georg F. W. Scheumann, J. F. Henry |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Medullary cavity medicine.medical_treatment Thyroid carcinoma Internal Medicine medicine Carcinoma Humans Thyroid Neoplasms Lymph node Retrospective Studies business.industry Neck dissection medicine.disease Surgery Europe Dissection medicine.anatomical_structure Medullary carcinoma Carcinoma Medullary Lymphatic Metastasis Neck Dissection Lymphadenectomy Female Neoplasm Recurrence Local business |
| Zdroj: | Journal of internal medicine. 238(4) |
| ISSN: | 0954-6820 |
| Popis: | Clinical data of 139 patients with hereditary medullary thyroid carcinoma (HMTC) from nine european centres surgically treated from 1980 to 1991 were reviewed retrospectively to analyse the value of systematic versus selective lymphadenectomy (LA). Biochemical cure rate was significantly higher in patients who underwent LA compared to patients who did not. In nodal-positive HMTC, systematic LA compared to selective LA improved biochemical cure in small but not large tumours. In nodal-negative HMTC, systematic LA compared to selective LA could not improve biochemical cure in either small or large primary tumours. To prevent local recurrences with the risk of increased surgical and tumour-related morbidity, systematic LA should be performed in all HMTC patients regardless of the primary tumour stage. However, an improvement of biochemical cure by systematic LA seems to be possible only in nodal-positive small primary tumours without distant metastases. |
| Databáze: | OpenAIRE |
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