Associations of ankle-brachial index (ABI) with cerebral arterial disease and vascular events following ischemic stroke
| Autor: | Jennifer Justice F. Manzano, Deidre A De Silva, Hui Meng Chang, Christopher Chen, Jose Leonard R. Pascual, Meng-Cheong Wong |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Ultrasonography Doppler Transcranial Cerebral arteries Risk Assessment Severity of Illness Index Brain Ischemia Peripheral Arterial Disease Predictive Value of Tests Risk Factors Diabetes mellitus Internal medicine Severity of illness Odds Ratio Prevalence medicine Humans Ankle Brachial Index Carotid Stenosis Prospective Studies cardiovascular diseases Myocardial infarction Ultrasonography Doppler Color Risk factor Prospective cohort study Stroke Aged Singapore business.industry Incidence Atrial fibrillation Middle Aged medicine.disease body regions Logistic Models Multivariate Analysis cardiovascular system Cardiology Female Cerebral Arterial Diseases Cardiology and Cardiovascular Medicine business human activities |
| Zdroj: | Atherosclerosis. 223:219-222 |
| ISSN: | 0021-9150 |
| DOI: | 10.1016/j.atherosclerosis.2012.04.009 |
| Popis: | Low ankle-brachial index (ABI), indicative of peripheral arterial disease (PAD), is a risk factor for stroke. ABI has been shown to be associated with cerebral arterial disease and prognosis following stroke. We studied the associations of the degree of ABI lowering with extracranial carotid disease (ECD), intracranial large artery disease (ICLAD), and subsequent vascular events in a prospective cohort of acute ischemic stroke patients.ABI, extracranial and intracranial cerebral arteries were assessed in a blinded manner. ABI was categorized into 0.9-1.3 (normal), 0.8-0.89 (mildly lowered) and0.8 (severely lowered). Follow-up data at 1 year were obtained from standardized telephone interviews and verified with medical records.Among the 1311 patients, 73% had normal ABI, 13% had ABI 0.8-0.89 and 13% had ABI0.8. Compared to patients with normal ABI, those with ABI0.8 had higher prevalence of severe ECD (15% vs. 5%, p = 0.006) and ICLAD (72% vs. 48%, p = 0.003), even after adjustment for age, gender, hypertension, diabetes, hyperlipidemia, smoking, ischemic heart disease and atrial fibrillation (severe ECD p0.001, ICLAD p0.001). At 1 year, patients with ABI0.8 had a higher incidence of composite vascular events (19% vs. 11%, p = 0.02), stroke (15% vs. 10%, p = 0.06) and myocardial infarction (4% vs. 2%, p = 0.07) than patients with normal ABI.Among ischemic stroke patients, large cerebral arterial disease and incidence of subsequent vascular events at 1 year were associated with severe ABI lowering0.8, but not with mild ABI lowering (0.8-0.89). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect