Synthesis and biological evaluation of some 1,2-disubstituted benzimidazole derivatives as new potential anticancer agents
| Autor: | Gülsen Akalın Çiftçi, Zafer Asım Kaplancıklı, Şeref Demirayak, Şafak Ulusoylar Yıldırım, Leyla Yurttaş |
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| Přispěvatelé: | Anadolu Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Yurttaş, Leyla, Demirayak, Şeref, Çiftçi, Gülsen Akalın, Kaplancıklı, Zafer Asım |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Anticancer Activity
Benzimidazole Lung Neoplasms Magnetic Resonance Spectroscopy Pharmaceutical Science chemistry.chemical_element Antineoplastic Agents Breast Neoplasms Mass Spectrometry Potassium carbonate chemistry.chemical_compound Morpholine Carcinoma Non-Small-Cell Lung Cell Line Tumor Drug Discovery Spectroscopy Fourier Transform Infrared Flow Cytometric Analysis Organic chemistry Animals Humans MTT assay Thioamide chemistry.chemical_classification Glioma Flow Cytometry Sulfur Rats chemistry Proton NMR MCF-7 Cells Benzimidazoles Female Brdu Selectivity |
| Popis: | WOS: 000318810800008 PubMed ID: 23526768 The synthesis of some new 1-(2-aryl-2-oxoethyl)-2-[(morpholine-4-yl)thioxomethyl]benzimidazole derivatives and investigation of their anticancer activities were the aims of this work. 2-(Chloromethyl)benzimidazole compound was reacted with sulfur and morpholine via WillgerodtKindler reaction to give 2-[(morpholine-4-yl)thioxomethyl]benzimidazole. Then, the obtained compound was reacted with appropriate -bromoacetophenone derivatives in the presence of potassium carbonate to give the final products. Structure elucidation of the final compounds was achieved by FT-IR, 1H NMR spectroscopy and MS spectrometry. The anticancer activities of the final compounds were evaluated by MTT assay, BrdU method, and flow cytometric analysis on C6, MCF-7, and A549 tumor cells. Most of the synthesized compounds exhibited considerable selectivity against the MCF-7 and C6 cell lines. |
| Databáze: | OpenAIRE |
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