Absence of cortical demyelination in neuromyelitis optica
| Autor: | Raul N. Mandler, Claudia F. Lucchinetti, Brian G. Weinshenker, Kathy L. Newell, B.F.Gh. Popescu, Vanda A. Lennon, J.A. Cabrera-Gómez, Joseph E. Parisi, Sean J. Pittock |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Central nervous system disease Cerebellar Cortex Young Adult Neuroimaging Cortex (anatomy) medicine Cranial nerve disease Humans Aged Aged 80 and over Aquaporin 4 Cerebral Cortex Neuromyelitis optica business.industry Neuromyelitis Optica Articles Middle Aged medicine.disease medicine.anatomical_structure Cross-Sectional Studies Forebrain Optic nerve Immunohistochemistry Female Neurology (clinical) medicine.symptom business Neuroscience |
| Popis: | Objective: To asses the presence of cortical demyelination in brains of patients with neuromyelitis optica (NMO). NMO is an autoimmune inflammatory demyelinating disease that specifically targets aquaporin-4–rich regions of the CNS. Since aquaporin-4 is highly expressed in normal cortex, we anticipated that cortical demyelination may occur in NMO. Methods: This is a cross-sectional neuropathologic study performed on archival forebrain and cerebellar tissue sections from 19 autopsied patients with a clinically and/or pathologically confirmed NMO spectrum disorder. Results: Detailed immunohistochemical analyses of 19 archival NMO cases revealed preservation of aquaporin-4 in a normal distribution within cerebral and cerebellar cortices, and no evidence of cortical demyelination. Conclusions: This study provides a plausible explanation for the absence of a secondary progressive clinical course in NMO and shows that cognitive and cortical neuroimaging abnormalities previously reported in NMO cannot be attributed to cortical demyelination. Lack of cortical demyelination is another characteristic that further distinguishes NMO from MS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|