Prospective randomized trials on cytoreduction in ovarian cancer
| Autor: | D. Luesley, P. Van Geene |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Ovarian Neoplasms
medicine.medical_specialty business.industry General surgery General Medicine medicine.disease Prognosis Surgery law.invention Combined treatment Randomized controlled trial Gynecological malignancy law Ovarian carcinoma medicine Retrospective analysis Humans Female Prospective Studies Radical surgery Ovarian cancer business Cause of death Randomized Controlled Trials as Topic |
| Zdroj: | Annals of medicine. 27(1) |
| ISSN: | 0785-3890 |
| Popis: | Ovarian cancer remains the main cause of death from gynaecological malignancy in England and Wales. Since the reports by Griffiths et al. in the 1970s that optimal cytoreduction to less than or equal to 1.5 cm is associated with an increase in survival there has been a gradual trend towards more radical surgery aimed at maximal tumour reduction. Since these first reports many others have made similar observations, so that now maximal surgical endeavour aimed at cytoreduction is almost standard practice. However, the majority of these reports are based on retrospective analysis, small numbers, poor standardization of treatment and other methodological inconsistencies. To date, no prospective randomized trials have been completed to confirm Griffiths's findings. The authors propose the case for a randomized trial before accepting a new and potentially morbid procedure as standard practice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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