Topical apraclonidine testing discloses pupillary sympathetic denervation in diabetic patients
| Autor: | Sevim Kavuncu, Esin Firat, Tulay Kansu, Feray Koç |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Miosis
Male Sympathetic nervous system Sympathetic Nervous System Administration Topical Horner syndrome Autonomic Denervation Severity of Illness Index Pupil Clonidine medicine Mydriasis Humans Diabetic Nephropathies business.industry Middle Aged medicine.disease Ophthalmology medicine.anatomical_structure Instillation Drug Anesthesia Disease Progression Female Neurology (clinical) Apraclonidine medicine.symptom business Adrenergic alpha-Agonists medicine.drug |
| Zdroj: | Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society. 26(1) |
| ISSN: | 1070-8022 |
| Popis: | Background: Autonomic denervation is common in dia-betes mellitus (DM). Pupillary sympathetic denervation(PSD) has been found in Horner syndrome followinginstillation of apraclonidine 0.5%. We have applied thistechnique to investigate the prevalence of PSD in DM.Methods: Apraclonidine 0.5% was instilled in the eyes of50 patients with DM and 30 age-matched and gender-matched subjects without DM (control subjects). Pupildiameters (PD) were measured before and 60 minutes afterinstillation. The duration of DM and the degree of diabeticretinopathy (DR) were recorded for each patient.Results: Apraclonidine instillation caused an average of0.9 mm of mydriasis (range 0 to 4.5 mm) in DM and20.1 mm miosis (range 0.5 to 21 mm) in control subjects(P < 0.001). Mydriasis of at least 1 mm was observed in42% of DM patients. The change in PD was highly cor-related with the duration of DM (r = 0.368, P = 0.008) andthe presence of DR (r = 0.532, P < 0.001).Conclusion: Apraclonidine testing, which is easy toperform and not distressing to the patient, identified PSDinnearlyhalfofDMpatients, thedegreeofmydriasis beingcorrelated to the duration of DM and the presence of DR.(J Neuro-Ophthalmol 2006;26: 25–29) |
| Databáze: | OpenAIRE |
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