Effects of phenytoin on amygdaloid kindled seizures in the rat
| Autor: | Albert L. Ehle |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
Phenytoin medicine.medical_specialty Stimulation Therapeutic index Seizures Internal medicine otorhinolaryngologic diseases medicine Animals Evoked Potentials Kindling business.industry General Neuroscience digestive oral and skin physiology Amygdala Electric Stimulation Rats nervous system diseases stomatognathic diseases Endocrinology Anesthesia Neurology (clinical) business medicine.drug |
| Zdroj: | Electroencephalography and Clinical Neurophysiology. 48:102-105 |
| ISSN: | 0013-4694 |
| DOI: | 10.1016/0013-4694(80)90049-8 |
| Popis: | The effects of oral phenytoin (0.25 g/kg) on the evolution of amygdaloid seizures were investigated using the kindling technique in rats. By utilizing low intensity stimulation at threshold for after-discharge, it was found that phenytoin produced a 23% increase in threshold for after-discharge and generalized seizures in fully kindled rats with blood levels in the human therapeutic range. Although half of the animals demonstrated a block of after-discharge after Phenytoin was started when the stimulation intensity was increased, the phenytoin animals developed generalized seizures in the same manner as controls. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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