Effects of Exogenous Application of Corticotropin-Releasing Hormone to Slices of the Olfactory Cortex from Rats with an Active Strategy of Adaptive Behavior on the Water-Immersion Model of Depression
| Autor: | A. A. Mokrushin, O. G. Semenova, V. G. Shalyapina, A. H. Hama-Murad |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Adaptive behavior Olfactory system medicine.medical_specialty Behavior Animal Corticotropin-Releasing Hormone Depression GABAA receptor Glutamate receptor Olfactory Pathways General Medicine In Vitro Techniques Biology General Biochemistry Genetics and Molecular Biology Rats Disease Models Animal Corticotropin-releasing hormone Endocrinology Water immersion Internal medicine Excitatory postsynaptic potential medicine Animals Evoked Potentials Depression (differential diagnoses) |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 147:277-280 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-009-0491-5 |
| Popis: | Experiments were performed on male Wistar rats. The specimens with an active strategy of behavior were exposed to unavoidable water-immersion stress. Surviving slices of the olfactory cortex were obtained 10 days after stress. The neurohormone had a strong inhibitory effect in 40% slices from active rats. The activity of glutamate receptors decreased, while the function of GABA receptors increased in 60% slices. Our results indicate that the depressive state of behaviorally active animals due to exposure to unavoidable stress is not necessarily mediated by the corticoliberinergic mechanisms in cortical structures. |
| Databáze: | OpenAIRE |
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