Synthesis, characterization and antimicrobial studies of novel ONO donor hydrazone Schiff base complexes with some divalent metal (II) ions
| Autor: | Nilesh Govindrao Salunkhe, Chandrashekhar Arunrao Ladole, J.M. Barabde, Ravindra Bhaskar, Anand S. Aswar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
General Chemical Engineering
Hydrazone 02 engineering and technology 010402 general chemistry 01 natural sciences Medicinal chemistry Metal (II) complexes Metal lcsh:Chemistry chemistry.chemical_compound Schiff base Octahedral molecular geometry Spectroscopy chemistry.chemical_classification Ligand Biological activity Powder XRD General Chemistry Carbon-13 NMR 021001 nanoscience & nanotechnology Magnetic susceptibility 0104 chemical sciences chemistry lcsh:QD1-999 visual_art visual_art.visual_art_medium Proton NMR 0210 nano-technology |
| Zdroj: | Arabian Journal of Chemistry, Vol 13, Iss 8, Pp 6559-6567 (2020) |
| ISSN: | 1878-5352 |
| Popis: | Metal complexes of two general formulae [M(L)(Cl)(H2O)2] [M = Mn(II), Co(II), Ni(II) and Cu(II)] and [M(L)(H2O)] [M = Zn(II) and Cd(II)] with pyrazine-2-carbohydrazone of 2-hydroxy-5-methylacetophenone (H2L) are synthesized and characterized by microanalytical, thermal, magnetic susceptibility measurement, spectroscopic (IR, 1H NMR, 13C NMR), mass, molar conductance, X-ray powder diffraction, ESR and SEM studies. While the molar conductance measurements in DMSO indicated their non-electrolytic nature, the spectroscopic studies confirmed a tridentate ONO donor behaviour of the ligand towards the central metal ion. Based on the physico-chemical studies monomeric octahedral geometry around Mn(II), Co(II), Ni(II) and Cu(II) ions (i.e. for the first series of complexes) whereas tetrahedral to Zn(II) and Cd(II) ions (i.e. for the second series of complexes) are suggested. Based on the thermal behavior of the complexes, various kinetic and thermodynamic parameters were evaluated using Coats-Redfern method. The ligand and its metal complexes were screened for in vitro antibacterial and antifungal activity against Gram +ve S. aureus, B. subtilis and Gram –ve E. coli and S. typhi. and fungal strains, C. albicans and A. niger. The observed data infer promising biological activity of some of these complexes compared the parent ligand against all bacterial and fungal species. |
| Databáze: | OpenAIRE |
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