The flare-up reactions after systemic provocation in contact allergy to nickel and gold
| Autor: | Bert Björkner, Kjell Ohlsson, Halvor Möller, Magnus Bruze, Carina Linder |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Nickel allergy
Adult Male Allergy medicine.drug_class medicine.medical_treatment Sialoglycoproteins Provocation test Administration Oral Dermatology medicine.disease_cause Gold Sodium Thiomalate Injections Intramuscular Receptors Tumor Necrosis Factor Body Temperature Allergen Double-Blind Method Lipocalin-2 Antigens CD Nickel Proto-Oncogene Proteins medicine Immunology and Allergy Humans Aged Skin Oncogene Proteins business.industry Tumor Necrosis Factor-alpha Acute-phase protein Allergens Middle Aged Patch Tests Receptor antagonist medicine.disease Lipocalins Interleukin 1 Receptor Antagonist Protein Cytokine C-Reactive Protein Receptors Tumor Necrosis Factor Type I Immunology Dermatitis Allergic Contact Female business Carrier Proteins Acute-Phase Proteins |
| Zdroj: | Contact dermatitis. 40(4) |
| ISSN: | 0105-1873 |
| Popis: | In a controlled double-blind experimental study, patients with contact allergy to nickel or gold were exposed systemically to their contact allergen. Nickel sulfate was given orally, gold sodium thiomalate intramuscularly, and placebo by both routes. Clinical reactions including body temperature were followed and 7 plasma cytokines and acute phase reactants were assayed before and 24 h after provocation. Clinical flare-up, with reactivation of healing patch tests and/or toxicoderma-like reactions, was observed in patients receiving their specific allergen. A transient fever was noted in patients allergic to gold when exposed to gold, not in others. There was a significant increase in plasma tumour necrosis factor-alpha, soluble tumour necrosis factor receptor 1, interleukin-1 receptor antagonist, and neutrophil gelatinase associated lipocalin in patients allergic to gold when exposed to gold allergen. Furthermore, in patients allergic to nickel exposed to nickel allergen there was a highly significant increase in plasma soluble tumour necrosis factor receptor 1. Interferon-gamma, interleukin-4, and C-reactive protein did not increase in any of the patient groups. Clinical reactions during flare-up in contact allergy are accompanied by release in the blood of several cytokines. This release is not a consequence of a toxic effect or bound to a particular allergen. Instead, the cytokine release should be considered a general phenomenon characteristic of the flare-up in contact allergy. |
| Databáze: | OpenAIRE |
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