Phosphorylation meets nuclear import: a review
| Autor: | Jonathan D. Nardozzi, Gino Cingolani, Kaylen Lott |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
0303 health sciences
lcsh:Cytology lcsh:R lcsh:Medicine Review macromolecular substances Cell Biology Biology environment and public health Biochemistry Cell biology Biological pathway Dephosphorylation 03 medical and health sciences 0302 clinical medicine Cytoplasm Phosphorylation lcsh:QH573-671 Nuclear transport Nuclear pore Molecular Biology 030217 neurology & neurosurgery Nuclear localization sequence Function (biology) 030304 developmental biology |
| Zdroj: | Cell Communication and Signaling, Vol 8, Iss 1, p 32 (2010) Cell Communication and Signaling : CCS |
| ISSN: | 1478-811X |
| DOI: | 10.1186/1478-811x-8-32 |
| Popis: | Phosphorylation is the most common and pleiotropic modification in biology, which plays a vital role in regulating and finely tuning a multitude of biological pathways. Transport across the nuclear envelope is also an essential cellular function and is intimately linked to many degeneration processes that lead to disease. It is therefore not surprising that phosphorylation of cargos trafficking between the cytoplasm and nucleus is emerging as an important step to regulate nuclear availability, which directly affects gene expression, cell growth and proliferation. However, the literature on phosphorylation of nucleocytoplasmic trafficking cargos is often confusing. Phosphorylation, and its mirror process dephosphorylation, has been shown to have opposite and often contradictory effects on the ability of cargos to be transported across the nuclear envelope. Without a clear connection between attachment of a phosphate moiety and biological response, it is difficult to fully understand and predict how phosphorylation regulates nucleocytoplasmic trafficking. In this review, we will recapitulate clue findings in the field and provide some general rules on how reversible phosphorylation can affect the nuclear-cytoplasmic localization of substrates. This is only now beginning to emerge as a key regulatory step in biology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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