IFITM3 inhibits virus-triggered induction of type I interferon by mediating autophagosome-dependent degradation of IRF3
| Autor: | Cao-Qi Lei, Hong-Bing Shu, Li-Qun Jiang, Shuang Yan, Tian Xia, Yun-Hong Hu, Ji-Hua Guo, Yu Liu, Ming-Shun Sun |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Autophagosome Endosome viruses Immunology Biology 03 medical and health sciences 0302 clinical medicine RNA Virus Infections Interferon medicine Immunology and Allergy Humans RNA Viruses Receptor Gene knockdown Autophagy Autophagosomes Membrane Proteins RNA-Binding Proteins Research Highlight Transmembrane protein Cell biology 030104 developmental biology Infectious Diseases HEK293 Cells Interferon Type I Proteolysis Interferon Regulatory Factor-3 IRF3 030215 immunology medicine.drug HeLa Cells |
| Zdroj: | Cellular & Molecular Immunology |
| ISSN: | 2042-0226 |
| Popis: | Interferon-induced transmembrane protein 3 (IFITM3) is a restriction factor that can be induced by viral infection and interferons (IFNs). It inhibits the entry and replication of many viruses, which are independent of receptor usage but dependent on processes that occur in endosomes. In this study, we demonstrate that IFITM3 plays important roles in regulating the RNA-virus-triggered production of IFN-β in a negative-feedback manner. Overexpression of IFITM3 inhibited Sendai virus-triggered induction of IFN-β, whereas knockdown of IFITM3 had the opposite effect. We also showed that IFITM3 was constitutively associated with IRF3 and regulated the homeostasis of IRF3 by mediating the autophagic degradation of IRF3. These findings suggest a novel inhibitory function of IFITM3 on the RNA-virus-triggered production of type I IFNs and cellular antiviral responses. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink