Diagnostic sensitivity of culture and drug resistance patterns in Korean patients with intestinal tuberculosis

Autor: Kim D, Park Sh, Kim Kj, Byong Duk Ye, Kim Mn, Shim Ts, Yang Sk, Dong-Hoon Yang, Kim Jh, Lee Yj, Seung-Jae Myung, Kim Sh, J.-S. Byeon, Na Hk
Rok vydání: 2012
Předmět:
Male
Pathology
Biopsy
Antitubercular Agents
Colonoscopy
Drug resistance
Crohn Disease
Risk Factors
Drug Resistance
Multiple
Bacterial
Tuberculosis
Multidrug-Resistant
Aged
80 and over
medicine.diagnostic_test
biology
Middle Aged
Treatment Outcome
Infectious Diseases
Predictive value of tests
Female
Adult
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Tuberculosis
Adolescent
Colon
Microbial Sensitivity Tests
Risk Assessment
Sensitivity and Specificity
Diagnosis
Differential
Mycobacterium tuberculosis
Young Adult
Asian People
Predictive Value of Tests
Internal medicine
Republic of Korea
medicine
Humans
Risk factor
Aged
Retrospective Studies
Chi-Square Distribution
business.industry
Retrospective cohort study
biology.organism_classification
medicine.disease
Logistic Models
Tuberculosis
Gastrointestinal
Multivariate Analysis
business
Zdroj: The International Journal of Tuberculosis and Lung Disease. 16:799-804
ISSN: 1027-3719
Popis: SETTING It is challenging to differentiate between intestinal tuberculosis (ITB) and Crohn's disease in areas where TB is still prevalent. The use of diagnostic tools and verifying the drug resistance patterns of ITB can be helpful for its correct diagnosis. OBJECTIVE To determine the diagnostic sensitivity of a culture assay using colonoscopic biopsy specimens and the drug resistance patterns of Mycobacterium tuberculosis isolated from ITB. DESIGN Data from 400 patients diagnosed with ITB were retrospectively analysed. RESULTS Of the 400 patients, 170 (42.5%) were males; the median age at diagnosis was 40 years. The sensitivity of culture was 44.1% (145/329). Resistance to at least one anti-tuberculosis drug was identified in 13 (17.6%) and multidrug-resistant TB (MDR-TB) was diagnosed in two (2.7%) of the 74 patients for whom drug susceptibility testing was performed. Including M. tuberculosis isolated from respiratory specimens, the proportion of MDR-TB was 4.4% (5/113); previous anti-tuberculosis treatment was an independent risk factor for MDR-TB (26.7% vs. 1.0%, P < 0.01). CONCLUSION Culture of colonoscopic biopsy specimens shows substantial diagnostic sensitivity; the frequency of MDR-TB is higher in previously treated cases than in new cases.
Databáze: OpenAIRE
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