Stage I-IV Colorectal Cancer Prognosis Can Be Predicted by Type and Number of Intratumoral Macrophages and CLEVER-1(+) Vessel Density
| Autor: | Caj Haglund, Lotta Kemppinen, Ruth Fair-Mäkelä, Harri Mustonen, Annika Ålgars, Sirpa Jalkanen |
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| Přispěvatelé: | HUS Abdominal Center, Clinicum, Department of Surgery, CAN-PRO - Translational Cancer Medicine Program, Faculty of Medicine, II kirurgian klinikka |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cancer Research
POLARIZATION Colorectal cancer MICROSATELLITE INSTABILITY lymphatic vessel ANTIBODY ANTI-CLEVER-1 MAB 3122 Cancers colorectal cancer macrophage survival ACTIVATION 03 medical and health sciences CD68 CLEVER-1 0302 clinical medicine POOR-PROGNOSIS LYMPHATIC VESSELS medicine Lymphatic vessel Macrophage Stage (cooking) RC254-282 030304 developmental biology 0303 health sciences Tumor microenvironment business.industry Neoplasms. Tumors. Oncology. Including cancer and carcinogens NIVOLUMAB medicine.disease PD-1 BLOCKADE 3. Good health TUMOR-ASSOCIATED MACROPHAGES Lymphatic system medicine.anatomical_structure Oncology INFILTRATION 030220 oncology & carcinogenesis Cancer research Immunohistochemistry business |
| Zdroj: | Cancers; Volume 13; Issue 23; Pages: 5988 Cancers, Vol 13, Iss 5988, p 5988 (2021) |
| Popis: | Simple Summary Tumor-associated macrophages can either promote or prevent cancer growth depending on factors such as macrophage polarization status, tumor type, and disease stage. Macrophages and vessels interact with each other, and the number of lymphatic vessels also affects cancer survival. CLEVER-1 is a protein expressed both on immunosuppressive M2 macrophages and lymphatic vessels. The aim of this study was to validate our previous results regarding the prognostic role of CLEVER-1(+) macrophages, CD68(+) macrophages, and CLEVER-1(+) lymphatic vessels in stage I-IV colorectal cancer. The results indicate that the prognostic role of tumor-associated macrophages and lymphatic vessels changes during disease progression. The findings resemble our earlier results, but are not completely equal, which may be due to the different types of tumor samples used in the two studies (whole section vs. tissue microarray). Macrophages, which are key players in the tumor microenvironment and affect the prognosis of many cancers, interact with lymphatic vessels in tumor tissue. However, the prognostic role of tumor-associated macrophages (TAM) and lymphatic vessels in human colorectal cancer (CRC) remains controversial. We investigated the prognostic role of CD68(+) and CLEVER-1(+) (common lymphatic endothelial and vascular endothelial receptor 1) TAMs in addition to CLEVER-1(+) lymphatic vessels in 498 stage I-IV CRC patients. The molecular markers were detected by immunohistochemical (IHC) analysis. The results showed that, in early stage I CRC and in young patients (age below median |
| Databáze: | OpenAIRE |
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